Cherokee County, KS lies directly northeastward of Crawford & Bourbon Counties deeply embedded within southeast quadrant of Kansas State sharing boundaries with Woodson Co on North , Neosho & Labette Co on east , Crawford Co on West & Barton Co on South . This 795 Sq Miles land valley has been habited since late 19th century by primarily migrant homesteaders from southern states such as Arkansas & Mississippi looking for fresh start . According to latest census data , This unincorporated territory hosts more than 21000 inhabitants although City Of Columbus serves as primary hostel center for travelers alike & those interested in visiting its historical artifacts dating back civil war era alongside numerous Prehistoric sites throughout region .