| | Destin, FL | Anna Maria, FL | United States |
| Population | 13,751 | 944 | 329,725,481 |
| Female Population | 48.8% | 55.0% | 50.5% |
| Male Population | 51.2% | 45.0% | 49.5% |
| Median Age | 43.3 | 65.3 | 38.4 |
| space3 | | | |
| Population - 2010 | 12,159 | 1,503 | 309,327,143 |
| Population - 2000 | 11,119 | 1,814 | 285,036,114 |
| Population - 1990 | 8,080 | 1,744 | 251,960,433 |
| Pop. 2000 to Now | 28.5% | -2.2% | 15.6% |
| Pop. 1990 to Now | 76.8% | 1.8% | 30.8% |
| space4 | | | |
| Population Density | 1,788.4 | 1,277.4 | 93.4 |
| Land Area | 7.7 | 0.7 | 3,531,905.4 |
| Water Area | 0.8 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Destin, FL | Anna Maria, FL | United States |
| Age 0 to 4 | 4.3% | 0.8% | 5.9% |
| Age 5 to 9 | 6.0% | 1.1% | 6.1% |
| Age 10 to 14 | 3.3% | 0.6% | 6.6% |
| Age 15 to 17 | 3.2% | 0.5% | 3.9% |
| Age 18 to 20 | 2.6% | 0.0% | 4.0% |
| Age 21 to 24 | 3.2% | 1.5% | 5.2% |
| Age 25 to 34 | 13.4% | 2.0% | 13.8% |
| Age 35 to 44 | 15.7% | 0.8% | 12.9% |
| Age 45 to 54 | 13.9% | 4.2% | 12.6% |
| Age 55 to 59 | 8.0% | 6.6% | 6.7% |
| Age 60 to 64 | 8.3% | 30.8% | 6.3% |
| Age 65 to 74 | 12.9% | 25.8% | 9.6% |
| Age 75 to 84 | 4.1% | 16.5% | 4.5% |
| Age 85 and over | 1.0% | 8.6% | 1.9% |
| space1 | | | |
| Race | | | |
| | Destin, FL | Anna Maria, FL | United States |
| White | 81.2% | 96.5% | 59.4% |
| Black | 2.5% | 0.0% | 12.2% |
| Asian | 1.1% | 0.0% | 5.6% |
| Native American | 0.1% | 0.6% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.4% | 0.0% | 0.4% |
| Two or More Races | 6.8% | 0.7% | 3.2% |
| Hispanic | 7.8% | 2.1% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Destin, FL | Anna Maria, FL | United States |
| Married Population | 51.8% | 67.7% | 49.8% |
| Currently Married | 48.8% | 67.1% | 48.0% |
| Married but Separated | 3.0% | 0.7% | 1.8% |
| Single Population | 48.2% | 32.3% | 50.2% |
| Never Married | 30.8% | 10.2% | 33.8% |
| Divorced | 13.6% | 8.0% | 10.8% |
| Widowed | 3.8% | 14.0% | 5.6% |
| space5 | | | |
| Household Size | 2.19 | 1.71 | 2.60 |
| Households | 6,201 | 551 | 124,010,992 |
| Family Households | 3,482 | 289 | 80,755,759 |
| Married couple, w/children | 25.4% | 2.4% | 30.5% |
| Married couple, no children | 55.2% | 90.3% | 42.9% |
| Non Family Households | 2,719 | 262 | 43,255,233 |
| Single householder, w/children | 11.5% | 1.4% | 15.8% |
| Single householder, no children | 8.0% | 5.9% | 10.8% |