| | Middletown, PA | Harrisburg, PA | United States |
| Population | 9,469 | 49,969 | 329,725,481 |
| Female Population | 49.6% | 51.5% | 50.5% |
| Male Population | 50.4% | 48.5% | 49.5% |
| Median Age | 34.3 | 31.6 | 38.4 |
| space3 | | | |
| Population - 2010 | 8,948 | 49,513 | 309,327,143 |
| Population - 2000 | 9,242 | 48,950 | 285,036,114 |
| Population - 1990 | 9,254 | 52,376 | 251,960,433 |
| Pop. 2000 to Now | 4.1% | 0.8% | 15.6% |
| Pop. 1990 to Now | 4.0% | -5.8% | 30.8% |
| space4 | | | |
| Population Density | 4,664.5 | 6,154.6 | 93.4 |
| Land Area | 2.0 | 8.1 | 3,531,905.4 |
| Water Area | 0.1 | 3.7 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Middletown, PA | Harrisburg, PA | United States |
| Age 0 to 4 | 6.4% | 8.6% | 5.9% |
| Age 5 to 9 | 5.6% | 8.1% | 6.1% |
| Age 10 to 14 | 4.7% | 8.6% | 6.6% |
| Age 15 to 17 | 3.2% | 3.6% | 3.9% |
| Age 18 to 20 | 4.0% | 3.4% | 4.0% |
| Age 21 to 24 | 7.5% | 5.7% | 5.2% |
| Age 25 to 34 | 20.2% | 17.4% | 13.8% |
| Age 35 to 44 | 9.6% | 11.1% | 12.9% |
| Age 45 to 54 | 10.0% | 11.2% | 12.6% |
| Age 55 to 59 | 8.0% | 6.7% | 6.7% |
| Age 60 to 64 | 5.5% | 4.8% | 6.3% |
| Age 65 to 74 | 8.3% | 6.5% | 9.6% |
| Age 75 to 84 | 4.1% | 3.4% | 4.5% |
| Age 85 and over | 3.1% | 0.9% | 1.9% |
| space1 | | | |
| Race | | | |
| | Middletown, PA | Harrisburg, PA | United States |
| White | 75.3% | 24.4% | 59.4% |
| Black | 8.7% | 44.0% | 12.2% |
| Asian | 5.4% | 2.6% | 5.6% |
| Native American | 0.1% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.3% | 0.4% | 0.4% |
| Two or More Races | 2.6% | 3.3% | 3.2% |
| Hispanic | 7.6% | 25.1% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Middletown, PA | Harrisburg, PA | United States |
| Married Population | 37.1% | 31.4% | 49.8% |
| Currently Married | 34.3% | 27.3% | 48.0% |
| Married but Separated | 2.8% | 4.2% | 1.8% |
| Single Population | 62.9% | 68.6% | 50.2% |
| Never Married | 40.6% | 49.4% | 33.8% |
| Divorced | 14.4% | 13.0% | 10.8% |
| Widowed | 7.9% | 6.1% | 5.6% |
| space5 | | | |
| Household Size | 2.18 | 2.33 | 2.60 |
| Households | 4,267 | 20,953 | 124,010,992 |
| Family Households | 2,103 | 10,507 | 80,755,759 |
| Married couple, w/children | 24.0% | 15.0% | 30.5% |
| Married couple, no children | 38.2% | 26.1% | 42.9% |
| Non Family Households | 2,164 | 10,446 | 43,255,233 |
| Single householder, w/children | 22.5% | 40.0% | 15.8% |
| Single householder, no children | 15.3% | 18.9% | 10.8% |