| | Natchez, MS | Tupelo, MS | United States |
| Population | 14,435 | 37,872 | 329,725,481 |
| Female Population | 56.9% | 54.0% | 50.5% |
| Male Population | 43.1% | 46.0% | 49.5% |
| Median Age | 39.6 | 37.7 | 38.4 |
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| Population - 2010 | 15,716 | 37,634 | 309,327,143 |
| Population - 2000 | 18,464 | 34,211 | 285,036,114 |
| Population - 1990 | 19,460 | 30,685 | 251,960,433 |
| Pop. 2000 to Now | -22.2% | 12.0% | 15.6% |
| Pop. 1990 to Now | -26.2% | 24.8% | 30.8% |
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| Population Density | 912.7 | 588.4 | 93.4 |
| Land Area | 15.8 | 64.4 | 3,531,905.4 |
| Water Area | 0.6 | 0.3 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Natchez, MS | Tupelo, MS | United States |
| Age 0 to 4 | 7.0% | 6.9% | 5.9% |
| Age 5 to 9 | 8.2% | 7.9% | 6.1% |
| Age 10 to 14 | 7.7% | 6.4% | 6.6% |
| Age 15 to 17 | 4.5% | 3.9% | 3.9% |
| Age 18 to 20 | 2.3% | 3.4% | 4.0% |
| Age 21 to 24 | 5.0% | 4.2% | 5.2% |
| Age 25 to 34 | 10.8% | 14.0% | 13.8% |
| Age 35 to 44 | 9.9% | 13.3% | 12.9% |
| Age 45 to 54 | 12.0% | 12.7% | 12.6% |
| Age 55 to 59 | 5.5% | 6.0% | 6.7% |
| Age 60 to 64 | 6.6% | 5.8% | 6.3% |
| Age 65 to 74 | 10.7% | 8.2% | 9.6% |
| Age 75 to 84 | 7.4% | 5.5% | 4.5% |
| Age 85 and over | 2.2% | 1.7% | 1.9% |
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| Race | | | |
| | Natchez, MS | Tupelo, MS | United States |
| White | 31.6% | 54.9% | 59.4% |
| Black | 61.0% | 36.7% | 12.2% |
| Asian | 0.5% | 0.8% | 5.6% |
| Native American | 0.1% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.4% | 0.2% |
| Other | 0.2% | 0.7% | 0.4% |
| Two or More Races | 1.2% | 2.0% | 3.2% |
| Hispanic | 5.4% | 4.3% | 18.4% |
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| Marriage & Family | | | |
| | Natchez, MS | Tupelo, MS | United States |
| Married Population | 33.4% | 49.6% | 49.8% |
| Currently Married | 29.8% | 47.1% | 48.0% |
| Married but Separated | 3.6% | 2.5% | 1.8% |
| Single Population | 66.6% | 50.4% | 50.2% |
| Never Married | 45.2% | 30.3% | 33.8% |
| Divorced | 12.8% | 13.7% | 10.8% |
| Widowed | 8.6% | 6.4% | 5.6% |
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| Household Size | 2.35 | 2.44 | 2.60 |
| Households | 6,028 | 15,238 | 124,010,992 |
| Family Households | 3,404 | 9,514 | 80,755,759 |
| Married couple, w/children | 9.8% | 29.2% | 30.5% |
| Married couple, no children | 31.8% | 40.6% | 42.9% |
| Non Family Households | 2,624 | 5,724 | 43,255,233 |
| Single householder, w/children | 41.4% | 18.7% | 15.8% |
| Single householder, no children | 17.0% | 11.4% | 10.8% |