| | Orangeburg, SC | Dothan, AL | United States |
| Population | 12,779 | 70,318 | 329,725,481 |
| Female Population | 51.6% | 52.1% | 50.5% |
| Male Population | 48.4% | 47.9% | 49.5% |
| Median Age | 36.1 | 40 | 38.4 |
| space3 | | | |
| Population - 2010 | 13,785 | 66,177 | 309,327,143 |
| Population - 2000 | 12,765 | 57,737 | 285,036,114 |
| Population - 1990 | 13,739 | 53,589 | 251,960,433 |
| Pop. 2000 to Now | -2.4% | 20.2% | 15.6% |
| Pop. 1990 to Now | -9.3% | 29.5% | 30.8% |
| space4 | | | |
| Population Density | 1,419.4 | 783.9 | 93.4 |
| Land Area | 9.0 | 89.7 | 3,531,905.4 |
| Water Area | 0.0 | 0.3 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Orangeburg, SC | Dothan, AL | United States |
| Age 0 to 4 | 4.1% | 6.3% | 5.9% |
| Age 5 to 9 | 4.6% | 6.4% | 6.1% |
| Age 10 to 14 | 6.1% | 6.5% | 6.6% |
| Age 15 to 17 | 1.6% | 3.9% | 3.9% |
| Age 18 to 20 | 12.4% | 3.4% | 4.0% |
| Age 21 to 24 | 7.3% | 4.3% | 5.2% |
| Age 25 to 34 | 12.9% | 13.2% | 13.8% |
| Age 35 to 44 | 11.2% | 12.5% | 12.9% |
| Age 45 to 54 | 10.7% | 12.5% | 12.6% |
| Age 55 to 59 | 5.4% | 6.6% | 6.7% |
| Age 60 to 64 | 6.3% | 6.4% | 6.3% |
| Age 65 to 74 | 9.4% | 10.7% | 9.6% |
| Age 75 to 84 | 4.8% | 5.1% | 4.5% |
| Age 85 and over | 3.2% | 2.1% | 1.9% |
| space1 | | | |
| Race | | | |
| | Orangeburg, SC | Dothan, AL | United States |
| White | 26.1% | 57.4% | 59.4% |
| Black | 70.8% | 34.3% | 12.2% |
| Asian | 0.2% | 1.3% | 5.6% |
| Native American | 0.0% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 1.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.5% | 0.4% |
| Two or More Races | 1.3% | 2.7% | 3.2% |
| Hispanic | 0.6% | 3.6% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Orangeburg, SC | Dothan, AL | United States |
| Married Population | 30.7% | 47.1% | 49.8% |
| Currently Married | 26.7% | 44.7% | 48.0% |
| Married but Separated | 4.0% | 2.4% | 1.8% |
| Single Population | 69.3% | 52.9% | 50.2% |
| Never Married | 55.8% | 32.0% | 33.8% |
| Divorced | 6.6% | 13.1% | 10.8% |
| Widowed | 7.0% | 7.8% | 5.6% |
| space5 | | | |
| Household Size | 2.15 | 2.50 | 2.60 |
| Households | 4,831 | 27,751 | 124,010,992 |
| Family Households | 2,394 | 17,369 | 80,755,759 |
| Married couple, w/children | 10.4% | 23.7% | 30.5% |
| Married couple, no children | 44.5% | 43.4% | 42.9% |
| Non Family Households | 2,437 | 10,382 | 43,255,233 |
| Single householder, w/children | 23.2% | 19.9% | 15.8% |
| Single householder, no children | 21.9% | 13.0% | 10.8% |