| | Worcester, MA | Guilderland, NY | United States |
| Population | 203,867 | 36,862 | 329,725,481 |
| Female Population | 50.7% | 49.3% | 50.5% |
| Male Population | 49.3% | 50.7% | 49.5% |
| Median Age | 34.4 | 39.6 | 38.4 |
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| Population - 2010 | 181,762 | 35,347 | 309,327,143 |
| Population - 2000 | 172,648 | 32,688 | 285,036,114 |
| Population - 1990 | 169,759 | 28,764 | 251,960,433 |
| Pop. 2000 to Now | 6.9% | 9.3% | 15.6% |
| Pop. 1990 to Now | 8.7% | 24.3% | 30.8% |
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| Population Density | 5,456.8 | 636.6 | 93.4 |
| Land Area | 37.4 | 57.9 | 3,531,905.4 |
| Water Area | 1.1 | 0.9 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Worcester, MA | Guilderland, NY | United States |
| Age 0 to 4 | 5.3% | 4.9% | 5.9% |
| Age 5 to 9 | 5.2% | 4.8% | 6.1% |
| Age 10 to 14 | 5.7% | 5.4% | 6.6% |
| Age 15 to 17 | 3.5% | 3.4% | 3.9% |
| Age 18 to 20 | 7.9% | 7.7% | 4.0% |
| Age 21 to 24 | 7.2% | 6.5% | 5.2% |
| Age 25 to 34 | 16.2% | 12.0% | 13.8% |
| Age 35 to 44 | 12.5% | 11.3% | 12.9% |
| Age 45 to 54 | 11.5% | 11.0% | 12.6% |
| Age 55 to 59 | 6.2% | 7.9% | 6.7% |
| Age 60 to 64 | 6.0% | 6.3% | 6.3% |
| Age 65 to 74 | 7.6% | 11.5% | 9.6% |
| Age 75 to 84 | 3.4% | 5.4% | 4.5% |
| Age 85 and over | 2.0% | 1.9% | 1.9% |
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| Race | | | |
| | Worcester, MA | Guilderland, NY | United States |
| White | 53.6% | 77.6% | 59.4% |
| Black | 11.6% | 4.4% | 12.2% |
| Asian | 6.8% | 9.4% | 5.6% |
| Native American | 0.2% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.1% | 0.2% |
| Other | 0.6% | 0.3% | 0.4% |
| Two or More Races | 3.3% | 3.2% | 3.2% |
| Hispanic | 23.9% | 5.0% | 18.4% |
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| Marriage & Family | | | |
| | Worcester, MA | Guilderland, NY | United States |
| Married Population | 36.0% | 50.9% | 49.8% |
| Currently Married | 34.0% | 50.1% | 48.0% |
| Married but Separated | 2.0% | 0.9% | 1.8% |
| Single Population | 64.0% | 49.1% | 50.2% |
| Never Married | 47.8% | 34.7% | 33.8% |
| Divorced | 11.3% | 9.6% | 10.8% |
| Widowed | 4.9% | 4.8% | 5.6% |
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| Household Size | 2.40 | 2.37 | 2.60 |
| Households | 78,780 | 14,666 | 124,010,992 |
| Family Households | 43,192 | 9,283 | 80,755,759 |
| Married couple, w/children | 25.6% | 33.6% | 30.5% |
| Married couple, no children | 34.6% | 48.0% | 42.9% |
| Non Family Households | 35,588 | 5,383 | 43,255,233 |
| Single householder, w/children | 24.3% | 10.7% | 15.8% |
| Single householder, no children | 15.5% | 7.7% | 10.8% |