Perry County lies close to Missouri’s Bootheel region along the Mississippi River and it is the 42nd most populous county therein with an estimated population of 18,872. The total area covered by Perry stands at 574 square miles and its county seat is Perryville which also happens to be its largest town in terms of population. With a median household income of $46,945 and scenic living alongside easy access to larger cities such as St. Louis and Memphis, Perry County offers great value for those looking for affordable rural living within Missouri.