| School Name | Grades | Address | Zip | Phone | County | Type | District Name |
| Athena Elementary School | K-6 | 3775 Athena School Rd
De Soto, MO | 63020 | (636) 586-1020 | Jefferson | public | Desoto 73 School District |
| Desoto Junior High School | 7-8 | 731 Amvets Dr
De Soto, MO | 63020 | (636) 586-1030 | Jefferson | public | Desoto 73 School District |
| Desoto Senior High School | 9-12 | 815 Amvets Dr
De Soto, MO | 63020 | (636) 586-1050 | Jefferson | public | Desoto 73 School District |
| St. Rose of Lima School | PK-8 | 523 S 4th St
De Soto, MO | 63020 | (636) 586-3594 | Jefferson | private | |
| Sunrise Elementary School | K-8 | 4485 Sunrise School Rd
De Soto, MO | 63020 | (636) 586-6660 | Jefferson | public | Sunrise R-IX School District |
| Vineland Elementary School | K-6 | 650 Vineland School Rd
De Soto, MO | 63020 | (636) 586-1010 | Jefferson | public | Desoto 73 School District |
