| School Name | Grades | Address | Zip | Phone | County | Type | District Name |
| Central High School | 9-12 | 310 US Hwy 61
New Madrid, MO | 63869 | (573) 688-2165 | New Madrid | public | New Madrid County R-I School District |
| Central Middle School | 6-8 | 308 US Hwy 61
New Madrid, MO | 63869 | (573) 688-2176 | New Madrid | public | New Madrid County R-I School District |
| Immaculate Conception School | PK-4, 6, 8 | 560 Powell St
New Madrid, MO | 63869 | (573) 748-5123 | New Madrid | private | |
| New Madrid Elementary School | PK-5 | 955 US Hwy 61
New Madrid, MO | 63869 | (573) 748-5568 | New Madrid | public | New Madrid County R-I School District |
| New Madrid R-I Tech Skills Center | 9-12 | 310 US Hwy 61
New Madrid, MO | 63869 | (573) 688-2161 | New Madrid | public | New Madrid County R-I School District |
