| School Name | Grades | Address | Zip | Phone | County | Type | District Name |
| All Sts. Episcopal Day School | PK-6 | 1425 Cherokee Rd
Florence, SC | 29501 | (843) 662-8134 | Florence | private | |
| Briggs Elementary School | K-6 | 1012 Congaree Dr
Florence, SC | 29501 | (843) 664-8169 | Florence | public | Florence 01 School District |
| Carver Elementary School | PK-4 | 515 North Cashua Dr
Florence, SC | 29501 | (843) 664-8156 | Florence | public | Florence 01 School District |
| Center Day School | PK-4 | 534 Azarea Ln
Florence, SC | 29501 | (843) 669-7380 | Florence | private | |
| Choices Charter School | 7-12 | 1405 Poinsett Dr
Florence, SC | 29505 | (843) 664-8993 | Florence | charter | Darlington 01 School District |
| Delmae Elementary School | K-4 | 1211 South Cashua Dr
Florence, SC | 29501 | (843) 664-8448 | Florence | public | Florence 01 School District |
| Florence Adventist School | 1-8 | 3605 Advent Lane
Florence, SC | 29506 | (843) 669-9858 | Florence | private | |
| Florence Career Center | 9-12 | 126 East Howe Springs Rd
Florence, SC | 29505 | (843) 664-8465 | Florence | public | Florence 01 School District |
| Florence Christian School | PK-12 | P.O. Box 12809
Florence, SC | 29504 | (843) 662-0454 | Florence | private | |
| Greenwood Elementary School | K-6 | 2300 East Howe Springs Rd
Florence, SC | 29505 | (843) 664-8451 | Florence | public | Florence 01 School District |
| Henry L. Sneed Middle School | 7-8 | 1102 Ebenezer Rd
Florence, SC | 29501 | (843) 673-1199 | Florence | public | Florence 01 School District |
| Henry Timrod Elementary School | PK-6 | 1901 East Old Marion Hwy
Florence, SC | 29506 | (843) 664-8454 | Florence | public | Florence 01 School District |
| Maranatha Christian School | PK-11 | 2624 W Palmetto St
Florence, SC | 29501 | (843) 665-6395 | Florence | private | |
| McLaurin Elementary School | PK-4 | 1400 McMillan Ln
Florence, SC | 29506 | (843) 664-8457 | Florence | public | Florence 01 School District |
| Montessori School of Florence | PK-6 | 510 W Palmetto St
Florence, SC | 29501 | (843) 629-2920 | Florence | private | |
| Moore Intermed | 5-6 | 1101 Cheraw Dr
Florence, SC | 29501 | (843) 664-8171 | Florence | public | Florence 01 School District |
| North Vista Elementary School | PK-6 | 1100 North Irby St
Florence, SC | 29501 | (843) 664-8159 | Florence | public | Florence 01 School District |
| Oakland Ave SDA School | 12 | 803 Oakland Avenue
Florence, SC | 29506 | (843) 669-3777 | Florence | private | |
| Palmetto Youth Academy Charter | 3-6 | 1209 North Douglas
Florence, SC | 29501 | (843) 679-7070 | Florence | charter | Florence 01 School District |
| Poynor Childcare Center | PK-4 | 301 South Dargan St
Florence, SC | 29506 | (843) 673-1129 | Florence | public | Florence 01 School District |
| Royall Elementary School | K-6 | 1400 Woods Rd
Florence, SC | 29501 | (843) 664-8167 | Florence | public | Florence 01 School District |
| Shiloh Christian Academy | 1-12 | 1410 S Floyd Circle
Florence, SC | 29501 | (843) 664-0950 | Florence | private | |
| South Florence High School | 9-12 | 3200 South Irby St
Florence, SC | 29505 | (843) 664-8190 | Florence | public | Florence 01 School District |
| Southside Middle School | 7-8 | 200 East Howe Springs Rd
Florence, SC | 29505 | (843) 664-8467 | Florence | public | Florence 01 School District |
| St. Anthony Catholic School | PK-8 | P.O. Box 5327
Florence, SC | 29502 | (843) 662-1910 | Florence | private | |
| The Byrnes Schools | PK-12 | 1201 E Ashby Rd
Florence, SC | 29506 | (843) 662-0131 | Florence | private | |
| The Church of God of the Firstborn School | 4 | 3814 Colonial Road
Florence, SC | 29501 | (843) 665-9241 | Florence | private | |
| The King's Academy | PK-12 | 1015 S Ebenezer Rd
Florence, SC | 29501 | (843) 661-7464 | Florence | private | |
| Theodore Lester Elementary School | PK-6 | 3501 East Palmetto St
Florence, SC | 29506 | (843) 664-8459 | Florence | public | Florence 01 School District |
| Wallace Gregg Elementary School | K-6 | 515 Francis Marion Rd
Florence, SC | 29506 | (843) 664-8481 | Florence | public | Florence 01 School District |
| West Florence High School | 9-12 | 221 North Beltline Dr
Florence, SC | 29501 | (843) 664-8472 | Florence | public | Florence 01 School District |
| Williams Middle School | 7-8 | 1119 North Irby St
Florence, SC | 29501 | (843) 664-8162 | Florence | public | Florence 01 School District |
| Wilson Senior High School | 9-12 | 1411 Old Marion Hwy
Florence, SC | 29506 | (843) 664-8440 | Florence | public | Florence 01 School District |
