| School Name | Grades | Address | Zip | Phone | County | Type | District Name |
| Echo Valley Christian School | 1, 3, 5-7 | 265 Echo Valley Rd
Wytheville, VA | 24382 | (276) 228-2749 | Wythe | private | |
| George Wythe High School | 9-12 | 1 Maroon Way
Wytheville, VA | 24382 | (276) 228-3157 | Wythe | public | Wythe County Public Schools |
| Granite Christian Academy | K-12 | 1705 Peppers Ferry Road
Wytheville, VA | 24382 | (276) 228-3129 | Wythe | private | |
| Minnick Education Center - Wytheville | K-12 | 425 Grayson Road, Building 6
Wytheville, VA | 24382 | (276) 228-8088 | Wythe | private | |
| Scott Memorial Middle School | 6-8 | 950 South Seventh St
Wytheville, VA | 24382 | (276) 228-2851 | Wythe | public | Wythe County Public Schools |
| Sheffey Elementary School | K-5 | 621 Mountian View Rd
Wytheville, VA | 24382 | (276) 699-1771 | Wythe | public | Wythe County Public Schools |
| Spiller Elementary School | K-5 | 330 Tazewell St
Wytheville, VA | 24382 | (276) 228-3561 | Wythe | public | Wythe County Public Schools |
| Wythe County Tech Center | 9-12 | 1505 West Spiller St
Wytheville, VA | 24382 | (276) 228-5481 | Wythe | public | Wythe County Public Schools |
