| | Mechanicsburg, PA | Columbia, MD | United States |
| Population | 9,310 | 105,086 | 329,725,481 |
| Female Population | 48.5% | 51.9% | 50.5% |
| Male Population | 51.5% | 48.1% | 49.5% |
| Median Age | 38.1 | 38.9 | 38.4 |
| space3 | | | |
| Population - 2010 | 8,937 | 98,379 | 309,327,143 |
| Population - 2000 | 9,042 | 88,254 | 285,036,114 |
| Population - 1990 | 9,452 | 75,883 | 251,960,433 |
| Pop. 2000 to Now | -0.3% | 23.2% | 15.6% |
| Pop. 1990 to Now | -4.6% | 43.3% | 30.8% |
| space4 | | | |
| Population Density | 3,863.1 | 3,290.5 | 93.4 |
| Land Area | 2.4 | 31.9 | 3,531,905.4 |
| Water Area | 0.0 | 0.3 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Mechanicsburg, PA | Columbia, MD | United States |
| Age 0 to 4 | 4.3% | 5.5% | 5.9% |
| Age 5 to 9 | 7.4% | 5.4% | 6.1% |
| Age 10 to 14 | 6.9% | 6.4% | 6.6% |
| Age 15 to 17 | 1.8% | 3.9% | 3.9% |
| Age 18 to 20 | 1.4% | 3.6% | 4.0% |
| Age 21 to 24 | 5.1% | 5.2% | 5.2% |
| Age 25 to 34 | 17.6% | 14.4% | 13.8% |
| Age 35 to 44 | 13.9% | 14.1% | 12.9% |
| Age 45 to 54 | 10.4% | 13.3% | 12.6% |
| Age 55 to 59 | 9.8% | 6.8% | 6.7% |
| Age 60 to 64 | 5.0% | 5.8% | 6.3% |
| Age 65 to 74 | 8.6% | 8.9% | 9.6% |
| Age 75 to 84 | 6.0% | 4.7% | 4.5% |
| Age 85 and over | 1.8% | 2.1% | 1.9% |
| space1 | | | |
| Race | | | |
| | Mechanicsburg, PA | Columbia, MD | United States |
| White | 84.7% | 44.8% | 59.4% |
| Black | 2.1% | 27.2% | 12.2% |
| Asian | 1.6% | 13.3% | 5.6% |
| Native American | 0.0% | 0.3% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.7% | 0.4% |
| Two or More Races | 4.4% | 5.0% | 3.2% |
| Hispanic | 7.2% | 8.6% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Mechanicsburg, PA | Columbia, MD | United States |
| Married Population | 50.1% | 49.7% | 49.8% |
| Currently Married | 47.3% | 48.3% | 48.0% |
| Married but Separated | 2.8% | 1.4% | 1.8% |
| Single Population | 49.9% | 50.3% | 50.2% |
| Never Married | 31.2% | 34.8% | 33.8% |
| Divorced | 12.2% | 10.1% | 10.8% |
| Widowed | 6.5% | 5.4% | 5.6% |
| space5 | | | |
| Household Size | 2.29 | 2.55 | 2.60 |
| Households | 4,037 | 40,937 | 124,010,992 |
| Family Households | 2,496 | 27,463 | 80,755,759 |
| Married couple, w/children | 25.3% | 30.4% | 30.5% |
| Married couple, no children | 45.7% | 41.4% | 42.9% |
| Non Family Households | 1,541 | 13,474 | 43,255,233 |
| Single householder, w/children | 15.4% | 14.3% | 15.8% |
| Single householder, no children | 13.6% | 13.9% | 10.8% |