| | Wilkes-Barre, PA | Bethlehem, PA | United States |
| Population | 44,086 | 75,599 | 329,725,481 |
| Female Population | 50.9% | 52.2% | 50.5% |
| Male Population | 49.1% | 47.9% | 49.5% |
| Median Age | 34.7 | 36.4 | 38.4 |
| space3 | | | |
| Population - 2010 | 41,502 | 74,974 | 309,327,143 |
| Population - 2000 | 43,123 | 71,329 | 285,036,114 |
| Population - 1990 | 47,523 | 71,428 | 251,960,433 |
| Pop. 2000 to Now | -5.9% | 5.8% | 15.6% |
| Pop. 1990 to Now | -14.6% | 5.7% | 30.8% |
| space4 | | | |
| Population Density | 6,316.1 | 3,955.0 | 93.4 |
| Land Area | 7.0 | 19.1 | 3,531,905.4 |
| Water Area | 0.3 | 0.3 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Wilkes-Barre, PA | Bethlehem, PA | United States |
| Age 0 to 4 | 6.5% | 5.0% | 5.9% |
| Age 5 to 9 | 6.2% | 4.4% | 6.1% |
| Age 10 to 14 | 5.7% | 5.2% | 6.6% |
| Age 15 to 17 | 4.3% | 3.0% | 3.9% |
| Age 18 to 20 | 6.8% | 8.7% | 4.0% |
| Age 21 to 24 | 5.7% | 7.5% | 5.2% |
| Age 25 to 34 | 15.3% | 14.6% | 13.8% |
| Age 35 to 44 | 13.1% | 11.7% | 12.9% |
| Age 45 to 54 | 10.1% | 10.6% | 12.6% |
| Age 55 to 59 | 5.6% | 5.5% | 6.7% |
| Age 60 to 64 | 5.0% | 5.8% | 6.3% |
| Age 65 to 74 | 8.5% | 9.8% | 9.6% |
| Age 75 to 84 | 4.7% | 5.2% | 4.5% |
| Age 85 and over | 2.5% | 3.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Wilkes-Barre, PA | Bethlehem, PA | United States |
| White | 56.2% | 55.8% | 59.4% |
| Black | 10.9% | 8.2% | 12.2% |
| Asian | 2.6% | 2.9% | 5.6% |
| Native American | 0.2% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.4% | 0.4% |
| Two or More Races | 3.2% | 2.6% | 3.2% |
| Hispanic | 26.9% | 30.1% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Wilkes-Barre, PA | Bethlehem, PA | United States |
| Married Population | 36.4% | 37.6% | 49.8% |
| Currently Married | 33.6% | 35.4% | 48.0% |
| Married but Separated | 2.8% | 2.2% | 1.8% |
| Single Population | 63.6% | 62.4% | 50.2% |
| Never Married | 47.7% | 45.0% | 33.8% |
| Divorced | 8.9% | 10.9% | 10.8% |
| Widowed | 7.0% | 6.6% | 5.6% |
| space5 | | | |
| Household Size | 2.45 | 2.33 | 2.60 |
| Households | 16,614 | 29,874 | 124,010,992 |
| Family Households | 9,871 | 16,673 | 80,755,759 |
| Married couple, w/children | 19.8% | 19.4% | 30.5% |
| Married couple, no children | 35.9% | 43.5% | 42.9% |
| Non Family Households | 6,743 | 13,201 | 43,255,233 |
| Single householder, w/children | 30.2% | 21.5% | 15.8% |
| Single householder, no children | 14.1% | 15.6% | 10.8% |