| | Brookline, MA | Santa Clara, CA | United States |
| Population | 62,620 | 127,922 | 329,725,481 |
| Female Population | 54.1% | 47.8% | 50.5% |
| Male Population | 45.9% | 52.2% | 49.5% |
| Median Age | 35.3 | 34 | 38.4 |
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| Population - 2010 | 58,740 | 116,857 | 309,327,143 |
| Population - 2000 | 57,107 | 102,361 | 285,036,114 |
| Population - 1990 | 54,718 | 93,613 | 251,960,433 |
| Pop. 2000 to Now | 3.4% | 28.0% | 15.6% |
| Pop. 1990 to Now | 7.9% | 40.0% | 30.8% |
| space4 | | | |
| Population Density | 9,277.0 | 6,952.7 | 93.4 |
| Land Area | 6.8 | 18.4 | 3,531,905.4 |
| Water Area | 0.1 | 0.0 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Brookline, MA | Santa Clara, CA | United States |
| Age 0 to 4 | 5.6% | 6.6% | 5.9% |
| Age 5 to 9 | 5.0% | 5.6% | 6.1% |
| Age 10 to 14 | 5.9% | 4.2% | 6.6% |
| Age 15 to 17 | 3.1% | 2.8% | 3.9% |
| Age 18 to 20 | 2.8% | 4.8% | 4.0% |
| Age 21 to 24 | 9.4% | 5.5% | 5.2% |
| Age 25 to 34 | 17.8% | 22.4% | 13.8% |
| Age 35 to 44 | 13.1% | 15.6% | 12.9% |
| Age 45 to 54 | 11.6% | 11.6% | 12.6% |
| Age 55 to 59 | 4.8% | 5.5% | 6.7% |
| Age 60 to 64 | 4.9% | 4.5% | 6.3% |
| Age 65 to 74 | 9.1% | 5.9% | 9.6% |
| Age 75 to 84 | 5.1% | 3.4% | 4.5% |
| Age 85 and over | 1.9% | 1.5% | 1.9% |
| space1 | | | |
| Race | | | |
| | Brookline, MA | Santa Clara, CA | United States |
| White | 67.2% | 30.2% | 59.4% |
| Black | 2.2% | 2.7% | 12.2% |
| Asian | 17.8% | 45.7% | 5.6% |
| Native American | 0.1% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.7% | 0.2% |
| Other | 0.2% | 0.4% | 0.4% |
| Two or More Races | 5.9% | 4.3% | 3.2% |
| Hispanic | 6.6% | 15.8% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Brookline, MA | Santa Clara, CA | United States |
| Married Population | 47.2% | 53.3% | 49.8% |
| Currently Married | 46.5% | 51.7% | 48.0% |
| Married but Separated | 0.7% | 1.6% | 1.8% |
| Single Population | 52.8% | 46.7% | 50.2% |
| Never Married | 42.5% | 37.0% | 33.8% |
| Divorced | 6.1% | 6.4% | 10.8% |
| Widowed | 4.2% | 3.2% | 5.6% |
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| Household Size | 2.28 | 2.68 | 2.60 |
| Households | 26,762 | 45,830 | 124,010,992 |
| Family Households | 13,615 | 30,055 | 80,755,759 |
| Married couple, w/children | 41.1% | 38.7% | 30.5% |
| Married couple, no children | 42.4% | 42.1% | 42.9% |
| Non Family Households | 13,147 | 15,775 | 43,255,233 |
| Single householder, w/children | 8.0% | 8.3% | 15.8% |
| Single householder, no children | 8.5% | 11.0% | 10.8% |