| | Charleston, IL | Blytheville, AR | United States |
| Population | 18,130 | 13,559 | 329,725,481 |
| Female Population | 53.0% | 56.5% | 50.5% |
| Male Population | 47.0% | 43.5% | 49.5% |
| Median Age | 26.8 | 36.3 | 38.4 |
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| Population - 2010 | 21,856 | 15,555 | 309,327,143 |
| Population - 2000 | 21,039 | 18,272 | 285,036,114 |
| Population - 1990 | 20,398 | 22,906 | 251,960,433 |
| Pop. 2000 to Now | -4.8% | -27.7% | 15.6% |
| Pop. 1990 to Now | -1.8% | -42.3% | 30.8% |
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| Population Density | 2,057.7 | 653.8 | 93.4 |
| Land Area | 8.8 | 20.7 | 3,531,905.4 |
| Water Area | 0.7 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Charleston, IL | Blytheville, AR | United States |
| Age 0 to 4 | 3.8% | 8.0% | 5.9% |
| Age 5 to 9 | 3.8% | 9.7% | 6.1% |
| Age 10 to 14 | 4.0% | 4.5% | 6.6% |
| Age 15 to 17 | 1.7% | 5.2% | 3.9% |
| Age 18 to 20 | 15.2% | 2.7% | 4.0% |
| Age 21 to 24 | 18.1% | 6.5% | 5.2% |
| Age 25 to 34 | 15.1% | 12.1% | 13.8% |
| Age 35 to 44 | 9.4% | 13.2% | 12.9% |
| Age 45 to 54 | 7.6% | 10.5% | 12.6% |
| Age 55 to 59 | 5.1% | 7.2% | 6.7% |
| Age 60 to 64 | 4.7% | 4.7% | 6.3% |
| Age 65 to 74 | 6.0% | 11.0% | 9.6% |
| Age 75 to 84 | 3.5% | 3.0% | 4.5% |
| Age 85 and over | 2.0% | 1.8% | 1.9% |
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| Race | | | |
| | Charleston, IL | Blytheville, AR | United States |
| White | 84.1% | 30.8% | 59.4% |
| Black | 7.6% | 62.7% | 12.2% |
| Asian | 1.9% | 0.6% | 5.6% |
| Native American | 0.1% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.3% | 0.6% | 0.4% |
| Two or More Races | 2.6% | 1.0% | 3.2% |
| Hispanic | 3.4% | 4.1% | 18.4% |
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| Marriage & Family | | | |
| | Charleston, IL | Blytheville, AR | United States |
| Married Population | 32.1% | 42.3% | 49.8% |
| Currently Married | 30.9% | 39.1% | 48.0% |
| Married but Separated | 1.2% | 3.2% | 1.8% |
| Single Population | 67.9% | 57.7% | 50.2% |
| Never Married | 54.7% | 38.8% | 33.8% |
| Divorced | 9.0% | 13.4% | 10.8% |
| Widowed | 4.3% | 5.5% | 5.6% |
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| Household Size | 2.05 | 2.52 | 2.60 |
| Households | 7,188 | 5,349 | 124,010,992 |
| Family Households | 3,583 | 3,453 | 80,755,759 |
| Married couple, w/children | 23.2% | 15.0% | 30.5% |
| Married couple, no children | 44.1% | 39.4% | 42.9% |
| Non Family Households | 3,605 | 1,896 | 43,255,233 |
| Single householder, w/children | 19.0% | 31.3% | 15.8% |
| Single householder, no children | 13.8% | 14.3% | 10.8% |