| | Darlington, SC | Lancaster, SC | United States |
| Population | 6,153 | 8,489 | 329,725,481 |
| Female Population | 56.4% | 52.7% | 50.5% |
| Male Population | 43.6% | 47.4% | 49.5% |
| Median Age | 46.1 | 37 | 38.4 |
| space3 | | | |
| Population - 2010 | 6,370 | 8,736 | 309,327,143 |
| Population - 2000 | 6,720 | 8,177 | 285,036,114 |
| Population - 1990 | 7,311 | 8,914 | 251,960,433 |
| Pop. 2000 to Now | -12.2% | 12.0% | 15.6% |
| Pop. 1990 to Now | -19.3% | 2.7% | 30.8% |
| space4 | | | |
| Population Density | 1,353.2 | 1,318.0 | 93.4 |
| Land Area | 4.5 | 6.4 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Darlington, SC | Lancaster, SC | United States |
| Age 0 to 4 | 7.9% | 6.3% | 5.9% |
| Age 5 to 9 | 5.0% | 7.5% | 6.1% |
| Age 10 to 14 | 3.9% | 8.6% | 6.6% |
| Age 15 to 17 | 3.5% | 4.7% | 3.9% |
| Age 18 to 20 | 2.9% | 3.7% | 4.0% |
| Age 21 to 24 | 4.2% | 3.2% | 5.2% |
| Age 25 to 34 | 9.6% | 13.1% | 13.8% |
| Age 35 to 44 | 11.9% | 13.5% | 12.9% |
| Age 45 to 54 | 9.2% | 10.0% | 12.6% |
| Age 55 to 59 | 8.4% | 5.3% | 6.7% |
| Age 60 to 64 | 6.0% | 6.0% | 6.3% |
| Age 65 to 74 | 14.6% | 10.4% | 9.6% |
| Age 75 to 84 | 8.0% | 4.8% | 4.5% |
| Age 85 and over | 5.0% | 2.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Darlington, SC | Lancaster, SC | United States |
| White | 39.5% | 36.3% | 59.4% |
| Black | 57.7% | 51.5% | 12.2% |
| Asian | 0.0% | 0.3% | 5.6% |
| Native American | 0.0% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 2.4% | 3.0% | 3.2% |
| Hispanic | 0.4% | 8.8% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Darlington, SC | Lancaster, SC | United States |
| Married Population | 38.8% | 39.3% | 49.8% |
| Currently Married | 35.9% | 36.3% | 48.0% |
| Married but Separated | 2.9% | 3.0% | 1.8% |
| Single Population | 61.2% | 60.7% | 50.2% |
| Never Married | 37.0% | 41.5% | 33.8% |
| Divorced | 11.9% | 11.2% | 10.8% |
| Widowed | 12.3% | 7.9% | 5.6% |
| space5 | | | |
| Household Size | 2.28 | 2.50 | 2.60 |
| Households | 2,620 | 3,353 | 124,010,992 |
| Family Households | 1,597 | 2,114 | 80,755,759 |
| Married couple, w/children | 20.1% | 14.1% | 30.5% |
| Married couple, no children | 33.6% | 36.4% | 42.9% |
| Non Family Households | 1,023 | 1,239 | 43,255,233 |
| Single householder, w/children | 22.0% | 35.1% | 15.8% |
| Single householder, no children | 24.3% | 14.3% | 10.8% |