| | Florence, AL | Natchez, MS | United States |
| Population | 39,709 | 14,435 | 329,725,481 |
| Female Population | 53.6% | 56.9% | 50.5% |
| Male Population | 46.4% | 43.1% | 49.5% |
| Median Age | 35 | 39.6 | 38.4 |
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| Population - 2010 | 39,613 | 15,716 | 309,327,143 |
| Population - 2000 | 36,264 | 18,464 | 285,036,114 |
| Population - 1990 | 36,426 | 19,460 | 251,960,433 |
| Pop. 2000 to Now | 13.5% | -22.2% | 15.6% |
| Pop. 1990 to Now | 13.0% | -26.2% | 30.8% |
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| Population Density | 1,501.9 | 912.7 | 93.4 |
| Land Area | 26.4 | 15.8 | 3,531,905.4 |
| Water Area | 0.2 | 0.6 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Florence, AL | Natchez, MS | United States |
| Age 0 to 4 | 5.4% | 7.0% | 5.9% |
| Age 5 to 9 | 5.7% | 8.2% | 6.1% |
| Age 10 to 14 | 5.4% | 7.7% | 6.6% |
| Age 15 to 17 | 2.9% | 4.5% | 3.9% |
| Age 18 to 20 | 7.0% | 2.3% | 4.0% |
| Age 21 to 24 | 8.5% | 5.0% | 5.2% |
| Age 25 to 34 | 15.0% | 10.8% | 13.8% |
| Age 35 to 44 | 11.3% | 9.9% | 12.9% |
| Age 45 to 54 | 9.1% | 12.0% | 12.6% |
| Age 55 to 59 | 6.5% | 5.5% | 6.7% |
| Age 60 to 64 | 5.6% | 6.6% | 6.3% |
| Age 65 to 74 | 10.2% | 10.7% | 9.6% |
| Age 75 to 84 | 5.1% | 7.4% | 4.5% |
| Age 85 and over | 2.2% | 2.2% | 1.9% |
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| Race | | | |
| | Florence, AL | Natchez, MS | United States |
| White | 71.2% | 31.6% | 59.4% |
| Black | 18.6% | 61.0% | 12.2% |
| Asian | 0.9% | 0.5% | 5.6% |
| Native American | 0.4% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.4% | 0.2% | 0.4% |
| Two or More Races | 3.6% | 1.2% | 3.2% |
| Hispanic | 4.8% | 5.4% | 18.4% |
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| Marriage & Family | | | |
| | Florence, AL | Natchez, MS | United States |
| Married Population | 40.0% | 33.4% | 49.8% |
| Currently Married | 37.9% | 29.8% | 48.0% |
| Married but Separated | 2.1% | 3.6% | 1.8% |
| Single Population | 60.0% | 66.6% | 50.2% |
| Never Married | 37.9% | 45.2% | 33.8% |
| Divorced | 14.2% | 12.8% | 10.8% |
| Widowed | 7.8% | 8.6% | 5.6% |
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| Household Size | 2.25 | 2.35 | 2.60 |
| Households | 16,827 | 6,028 | 124,010,992 |
| Family Households | 9,253 | 3,404 | 80,755,759 |
| Married couple, w/children | 25.5% | 9.8% | 30.5% |
| Married couple, no children | 38.3% | 31.8% | 42.9% |
| Non Family Households | 7,574 | 2,624 | 43,255,233 |
| Single householder, w/children | 22.2% | 41.4% | 15.8% |
| Single householder, no children | 14.0% | 17.0% | 10.8% |