| | Holly Springs, MS | Oxford, MS | United States |
| Population | 6,743 | 25,859 | 329,725,481 |
| Female Population | 47.1% | 51.2% | 50.5% |
| Male Population | 52.9% | 48.8% | 49.5% |
| Median Age | 39.4 | 27.7 | 38.4 |
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| Population - 2010 | 7,791 | 22,249 | 309,327,143 |
| Population - 2000 | 7,957 | 11,756 | 285,036,114 |
| Population - 1990 | 7,261 | 9,984 | 251,960,433 |
| Pop. 2000 to Now | -3.4% | 143.6% | 15.6% |
| Pop. 1990 to Now | 5.8% | 186.8% | 30.8% |
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| Population Density | 527.8 | 1,568.5 | 93.4 |
| Land Area | 12.8 | 16.5 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Holly Springs, MS | Oxford, MS | United States |
| Age 0 to 4 | 4.0% | 5.3% | 5.9% |
| Age 5 to 9 | 4.4% | 4.3% | 6.1% |
| Age 10 to 14 | 3.9% | 5.2% | 6.6% |
| Age 15 to 17 | 2.8% | 2.2% | 3.9% |
| Age 18 to 20 | 8.7% | 9.8% | 4.0% |
| Age 21 to 24 | 5.1% | 16.3% | 5.2% |
| Age 25 to 34 | 16.4% | 17.5% | 13.8% |
| Age 35 to 44 | 15.7% | 11.8% | 12.9% |
| Age 45 to 54 | 12.0% | 7.8% | 12.6% |
| Age 55 to 59 | 9.3% | 3.0% | 6.7% |
| Age 60 to 64 | 6.2% | 3.4% | 6.3% |
| Age 65 to 74 | 6.7% | 7.4% | 9.6% |
| Age 75 to 84 | 2.6% | 4.1% | 4.5% |
| Age 85 and over | 2.2% | 1.9% | 1.9% |
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| Race | | | |
| | Holly Springs, MS | Oxford, MS | United States |
| White | 18.5% | 66.4% | 59.4% |
| Black | 78.5% | 25.6% | 12.2% |
| Asian | 0.0% | 2.7% | 5.6% |
| Native American | 0.1% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.4% | 0.4% |
| Two or More Races | 2.8% | 2.0% | 3.2% |
| Hispanic | 0.3% | 2.8% | 18.4% |
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| Marriage & Family | | | |
| | Holly Springs, MS | Oxford, MS | United States |
| Married Population | 28.5% | 35.3% | 49.8% |
| Currently Married | 25.9% | 34.7% | 48.0% |
| Married but Separated | 2.6% | 0.6% | 1.8% |
| Single Population | 71.5% | 64.7% | 50.2% |
| Never Married | 52.8% | 51.8% | 33.8% |
| Divorced | 12.2% | 8.9% | 10.8% |
| Widowed | 6.5% | 4.1% | 5.6% |
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| Household Size | 2.20 | 2.55 | 2.60 |
| Households | 2,192 | 9,891 | 124,010,992 |
| Family Households | 1,395 | 4,776 | 80,755,759 |
| Married couple, w/children | 7.3% | 32.4% | 30.5% |
| Married couple, no children | 30.8% | 46.0% | 42.9% |
| Non Family Households | 797 | 5,115 | 43,255,233 |
| Single householder, w/children | 33.8% | 15.3% | 15.8% |
| Single householder, no children | 28.0% | 6.3% | 10.8% |