| | Louisville, MS | Macon, MS | United States |
| Population | 6,108 | 2,590 | 329,725,481 |
| Female Population | 50.2% | 52.9% | 50.5% |
| Male Population | 49.8% | 47.1% | 49.5% |
| Median Age | 38.5 | 29.6 | 38.4 |
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| Population - 2010 | 6,616 | 2,734 | 309,327,143 |
| Population - 2000 | 7,006 | 2,461 | 285,036,114 |
| Population - 1990 | 7,169 | 2,256 | 251,960,433 |
| Pop. 2000 to Now | -15.4% | -3.1% | 15.6% |
| Pop. 1990 to Now | -17.3% | 5.7% | 30.8% |
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| Population Density | 404.6 | 676.4 | 93.4 |
| Land Area | 15.1 | 3.8 | 3,531,905.4 |
| Water Area | 0.2 | 0.0 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Louisville, MS | Macon, MS | United States |
| Age 0 to 4 | 4.5% | 7.4% | 5.9% |
| Age 5 to 9 | 7.6% | 11.1% | 6.1% |
| Age 10 to 14 | 10.3% | 12.8% | 6.6% |
| Age 15 to 17 | 4.2% | 4.1% | 3.9% |
| Age 18 to 20 | 6.0% | 4.4% | 4.0% |
| Age 21 to 24 | 3.1% | 3.5% | 5.2% |
| Age 25 to 34 | 10.2% | 15.3% | 13.8% |
| Age 35 to 44 | 12.4% | 8.1% | 12.9% |
| Age 45 to 54 | 8.8% | 9.8% | 12.6% |
| Age 55 to 59 | 8.8% | 6.1% | 6.7% |
| Age 60 to 64 | 5.6% | 3.9% | 6.3% |
| Age 65 to 74 | 8.5% | 8.8% | 9.6% |
| Age 75 to 84 | 7.6% | 2.1% | 4.5% |
| Age 85 and over | 2.4% | 2.6% | 1.9% |
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| Race | | | |
| | Louisville, MS | Macon, MS | United States |
| White | 33.1% | 12.9% | 59.4% |
| Black | 63.6% | 86.4% | 12.2% |
| Asian | 0.2% | 0.0% | 5.6% |
| Native American | 0.3% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 1.5% | 0.0% | 3.2% |
| Hispanic | 1.4% | 0.7% | 18.4% |
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| Marriage & Family | | | |
| | Louisville, MS | Macon, MS | United States |
| Married Population | 35.5% | 38.6% | 49.8% |
| Currently Married | 32.0% | 32.6% | 48.0% |
| Married but Separated | 3.5% | 6.0% | 1.8% |
| Single Population | 64.5% | 61.4% | 50.2% |
| Never Married | 50.1% | 43.2% | 33.8% |
| Divorced | 6.4% | 11.1% | 10.8% |
| Widowed | 8.0% | 7.1% | 5.6% |
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| Household Size | 2.61 | 3.15 | 2.60 |
| Households | 2,268 | 792 | 124,010,992 |
| Family Households | 1,439 | 576 | 80,755,759 |
| Married couple, w/children | 13.1% | 9.5% | 30.5% |
| Married couple, no children | 38.8% | 27.6% | 42.9% |
| Non Family Households | 829 | 216 | 43,255,233 |
| Single householder, w/children | 31.7% | 57.1% | 15.8% |
| Single householder, no children | 16.4% | 5.7% | 10.8% |