| | Maryland Heights, MO | Edwardsville, IL | United States |
| Population | 28,141 | 25,236 | 329,725,481 |
| Female Population | 51.3% | 52.3% | 50.5% |
| Male Population | 48.8% | 47.7% | 49.5% |
| Median Age | 36.3 | 28.7 | 38.4 |
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| Population - 2010 | 27,460 | 24,407 | 309,327,143 |
| Population - 2000 | 25,756 | 21,491 | 285,036,114 |
| Population - 1990 | 25,407 | 14,579 | 251,960,433 |
| Pop. 2000 to Now | 4.4% | 17.2% | 15.6% |
| Pop. 1990 to Now | 5.9% | 72.8% | 30.8% |
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| Population Density | 1,285.9 | 1,279.0 | 93.4 |
| Land Area | 21.9 | 19.7 | 3,531,905.4 |
| Water Area | 1.5 | 0.6 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Maryland Heights, MO | Edwardsville, IL | United States |
| Age 0 to 4 | 4.7% | 5.8% | 5.9% |
| Age 5 to 9 | 5.7% | 5.2% | 6.1% |
| Age 10 to 14 | 5.1% | 5.7% | 6.6% |
| Age 15 to 17 | 3.2% | 3.8% | 3.9% |
| Age 18 to 20 | 2.3% | 15.3% | 4.0% |
| Age 21 to 24 | 6.2% | 9.9% | 5.2% |
| Age 25 to 34 | 20.5% | 11.6% | 13.8% |
| Age 35 to 44 | 14.8% | 10.8% | 12.9% |
| Age 45 to 54 | 11.5% | 12.1% | 12.6% |
| Age 55 to 59 | 7.1% | 4.5% | 6.7% |
| Age 60 to 64 | 5.5% | 4.9% | 6.3% |
| Age 65 to 74 | 7.9% | 6.5% | 9.6% |
| Age 75 to 84 | 3.9% | 2.6% | 4.5% |
| Age 85 and over | 1.6% | 1.4% | 1.9% |
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| Race | | | |
| | Maryland Heights, MO | Edwardsville, IL | United States |
| White | 61.3% | 83.5% | 59.4% |
| Black | 14.2% | 8.6% | 12.2% |
| Asian | 17.0% | 2.5% | 5.6% |
| Native American | 0.0% | 0.3% | 0.6% |
| Hawaiian, Pacific Islander | 0.3% | 0.0% | 0.2% |
| Other | 0.2% | 0.1% | 0.4% |
| Two or More Races | 3.1% | 2.8% | 3.2% |
| Hispanic | 4.0% | 2.3% | 18.4% |
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| Marriage & Family | | | |
| | Maryland Heights, MO | Edwardsville, IL | United States |
| Married Population | 49.2% | 42.9% | 49.8% |
| Currently Married | 48.4% | 42.0% | 48.0% |
| Married but Separated | 0.8% | 0.9% | 1.8% |
| Single Population | 50.8% | 57.1% | 50.2% |
| Never Married | 35.5% | 45.3% | 33.8% |
| Divorced | 10.6% | 8.7% | 10.8% |
| Widowed | 4.8% | 3.0% | 5.6% |
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| Household Size | 2.19 | 2.57 | 2.60 |
| Households | 12,590 | 8,552 | 124,010,992 |
| Family Households | 6,993 | 5,214 | 80,755,759 |
| Married couple, w/children | 33.7% | 44.3% | 30.5% |
| Married couple, no children | 45.2% | 38.2% | 42.9% |
| Non Family Households | 5,597 | 3,338 | 43,255,233 |
| Single householder, w/children | 10.4% | 9.4% | 15.8% |
| Single householder, no children | 10.7% | 8.2% | 10.8% |