| | Penfield, NY | Lancaster, PA | United States |
| Population | 39,074 | 58,034 | 329,725,481 |
| Female Population | 52.8% | 52.3% | 50.5% |
| Male Population | 47.2% | 47.7% | 49.5% |
| Median Age | 45.7 | 32.3 | 38.4 |
| space3 | | | |
| Population - 2010 | 36,309 | 59,277 | 309,327,143 |
| Population - 2000 | 34,645 | 56,348 | 285,036,114 |
| Population - 1990 | 30,219 | 55,551 | 251,960,433 |
| Pop. 2000 to Now | 7.5% | 4.7% | 15.6% |
| Pop. 1990 to Now | 23.2% | 6.2% | 30.8% |
| space4 | | | |
| Population Density | 1,049.8 | 8,030.2 | 93.4 |
| Land Area | 37.2 | 7.2 | 3,531,905.4 |
| Water Area | 0.6 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Penfield, NY | Lancaster, PA | United States |
| Age 0 to 4 | 5.8% | 6.4% | 5.9% |
| Age 5 to 9 | 5.9% | 5.8% | 6.1% |
| Age 10 to 14 | 7.9% | 6.7% | 6.6% |
| Age 15 to 17 | 3.6% | 3.9% | 3.9% |
| Age 18 to 20 | 2.4% | 7.2% | 4.0% |
| Age 21 to 24 | 3.5% | 6.5% | 5.2% |
| Age 25 to 34 | 8.7% | 18.4% | 13.8% |
| Age 35 to 44 | 11.2% | 14.2% | 12.9% |
| Age 45 to 54 | 15.7% | 11.1% | 12.6% |
| Age 55 to 59 | 6.8% | 5.7% | 6.7% |
| Age 60 to 64 | 8.4% | 5.1% | 6.3% |
| Age 65 to 74 | 10.9% | 5.9% | 9.6% |
| Age 75 to 84 | 6.0% | 2.3% | 4.5% |
| Age 85 and over | 3.2% | 0.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Penfield, NY | Lancaster, PA | United States |
| White | 89.7% | 38.8% | 59.4% |
| Black | 1.3% | 13.0% | 12.2% |
| Asian | 3.1% | 3.2% | 5.6% |
| Native American | 0.1% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.1% | 0.1% | 0.4% |
| Two or More Races | 2.1% | 4.4% | 3.2% |
| Hispanic | 3.6% | 40.4% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Penfield, NY | Lancaster, PA | United States |
| Married Population | 61.4% | 36.5% | 49.8% |
| Currently Married | 60.9% | 34.3% | 48.0% |
| Married but Separated | 0.5% | 2.1% | 1.8% |
| Single Population | 38.6% | 63.5% | 50.2% |
| Never Married | 23.3% | 50.2% | 33.8% |
| Divorced | 8.0% | 10.4% | 10.8% |
| Widowed | 7.4% | 2.9% | 5.6% |
| space5 | | | |
| Household Size | 2.46 | 2.56 | 2.60 |
| Households | 15,636 | 21,266 | 124,010,992 |
| Family Households | 10,702 | 12,371 | 80,755,759 |
| Married couple, w/children | 34.9% | 23.4% | 30.5% |
| Married couple, no children | 52.6% | 33.0% | 42.9% |
| Non Family Households | 4,934 | 8,895 | 43,255,233 |
| Single householder, w/children | 7.6% | 27.7% | 15.8% |
| Single householder, no children | 4.9% | 15.9% | 10.8% |