| | Ponce de Leon, FL | Madison, FL | United States |
| Population | 776 | 2,903 | 329,725,481 |
| Female Population | 49.5% | 48.5% | 50.5% |
| Male Population | 50.5% | 51.5% | 49.5% |
| Median Age | 37.6 | 34.4 | 38.4 |
| space3 | | | |
| Population - 2010 | 578 | 3,030 | 309,327,143 |
| Population - 2000 | 457 | 3,061 | 285,036,114 |
| Population - 1990 | 406 | 3,345 | 251,960,433 |
| Pop. 2000 to Now | 24.5% | -8.9% | 15.6% |
| Pop. 1990 to Now | 40.2% | -16.6% | 30.8% |
| space4 | | | |
| Population Density | 156.4 | 1,101.3 | 93.4 |
| Land Area | 5.0 | 2.6 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Ponce de Leon, FL | Madison, FL | United States |
| Age 0 to 4 | 7.6% | 7.8% | 5.9% |
| Age 5 to 9 | 2.8% | 5.3% | 6.1% |
| Age 10 to 14 | 2.1% | 5.4% | 6.6% |
| Age 15 to 17 | 10.1% | 4.1% | 3.9% |
| Age 18 to 20 | 2.3% | 5.0% | 4.0% |
| Age 21 to 24 | 6.1% | 7.5% | 5.2% |
| Age 25 to 34 | 14.9% | 15.8% | 13.8% |
| Age 35 to 44 | 10.4% | 11.4% | 12.9% |
| Age 45 to 54 | 21.4% | 12.9% | 12.6% |
| Age 55 to 59 | 3.9% | 5.2% | 6.7% |
| Age 60 to 64 | 7.2% | 2.4% | 6.3% |
| Age 65 to 74 | 8.2% | 10.5% | 9.6% |
| Age 75 to 84 | 1.7% | 4.6% | 4.5% |
| Age 85 and over | 1.3% | 2.2% | 1.9% |
| space1 | | | |
| Race | | | |
| | Ponce de Leon, FL | Madison, FL | United States |
| White | 98.7% | 37.6% | 59.4% |
| Black | 0.0% | 55.8% | 12.2% |
| Asian | 0.0% | 0.0% | 5.6% |
| Native American | 0.0% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.3% | 0.4% |
| Two or More Races | 1.3% | 2.9% | 3.2% |
| Hispanic | 0.0% | 3.3% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Ponce de Leon, FL | Madison, FL | United States |
| Married Population | 33.9% | 32.9% | 49.8% |
| Currently Married | 32.1% | 31.8% | 48.0% |
| Married but Separated | 1.8% | 1.1% | 1.8% |
| Single Population | 66.1% | 67.1% | 50.2% |
| Never Married | 38.9% | 48.6% | 33.8% |
| Divorced | 17.4% | 10.6% | 10.8% |
| Widowed | 9.9% | 7.9% | 5.6% |
| space5 | | | |
| Household Size | 3.18 | 2.52 | 2.60 |
| Households | 244 | 1,104 | 124,010,992 |
| Family Households | 173 | 557 | 80,755,759 |
| Married couple, w/children | 37.0% | 29.1% | 30.5% |
| Married couple, no children | 15.0% | 23.2% | 42.9% |
| Non Family Households | 71 | 547 | 43,255,233 |
| Single householder, w/children | 31.8% | 26.9% | 15.8% |
| Single householder, no children | 16.2% | 20.8% | 10.8% |