| | Poplar Bluff, MO | Mount Vernon, IL | United States |
| Population | 16,318 | 14,614 | 329,725,481 |
| Female Population | 52.5% | 52.1% | 50.5% |
| Male Population | 47.5% | 48.0% | 49.5% |
| Median Age | 37.2 | 39 | 38.4 |
| space3 | | | |
| Population - 2010 | 17,035 | 15,170 | 309,327,143 |
| Population - 2000 | 16,651 | 16,269 | 285,036,114 |
| Population - 1990 | 16,996 | 16,988 | 251,960,433 |
| Pop. 2000 to Now | 0.9% | -10.8% | 15.6% |
| Pop. 1990 to Now | -1.1% | -14.6% | 30.8% |
| space4 | | | |
| Population Density | 1,242.0 | 1,002.3 | 93.4 |
| Land Area | 13.1 | 14.6 | 3,531,905.4 |
| Water Area | 0.1 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Poplar Bluff, MO | Mount Vernon, IL | United States |
| Age 0 to 4 | 7.5% | 6.7% | 5.9% |
| Age 5 to 9 | 6.8% | 7.6% | 6.1% |
| Age 10 to 14 | 6.0% | 5.3% | 6.6% |
| Age 15 to 17 | 5.2% | 3.5% | 3.9% |
| Age 18 to 20 | 3.4% | 3.3% | 4.0% |
| Age 21 to 24 | 4.3% | 4.4% | 5.2% |
| Age 25 to 34 | 13.6% | 14.9% | 13.8% |
| Age 35 to 44 | 11.4% | 11.7% | 12.9% |
| Age 45 to 54 | 9.7% | 11.4% | 12.6% |
| Age 55 to 59 | 5.2% | 5.5% | 6.7% |
| Age 60 to 64 | 7.1% | 5.4% | 6.3% |
| Age 65 to 74 | 10.0% | 10.9% | 9.6% |
| Age 75 to 84 | 7.3% | 6.6% | 4.5% |
| Age 85 and over | 2.4% | 3.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Poplar Bluff, MO | Mount Vernon, IL | United States |
| White | 79.9% | 74.5% | 59.4% |
| Black | 10.8% | 16.4% | 12.2% |
| Asian | 0.4% | 1.3% | 5.6% |
| Native American | 0.8% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.2% | 0.1% | 0.2% |
| Other | 0.1% | 0.2% | 0.4% |
| Two or More Races | 5.2% | 3.6% | 3.2% |
| Hispanic | 2.7% | 3.9% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Poplar Bluff, MO | Mount Vernon, IL | United States |
| Married Population | 38.4% | 39.5% | 49.8% |
| Currently Married | 35.1% | 38.3% | 48.0% |
| Married but Separated | 3.3% | 1.2% | 1.8% |
| Single Population | 61.6% | 60.5% | 50.2% |
| Never Married | 36.0% | 36.7% | 33.8% |
| Divorced | 17.9% | 14.9% | 10.8% |
| Widowed | 7.7% | 9.0% | 5.6% |
| space5 | | | |
| Household Size | 2.45 | 2.30 | 2.60 |
| Households | 6,390 | 6,167 | 124,010,992 |
| Family Households | 3,549 | 3,760 | 80,755,759 |
| Married couple, w/children | 17.2% | 15.0% | 30.5% |
| Married couple, no children | 41.2% | 39.0% | 42.9% |
| Non Family Households | 2,841 | 2,407 | 43,255,233 |
| Single householder, w/children | 32.5% | 30.4% | 15.8% |
| Single householder, no children | 9.1% | 15.6% | 10.8% |