| | Portsmouth, NH | Manchester, NH | United States |
| Population | 21,897 | 114,730 | 329,725,481 |
| Female Population | 52.5% | 49.7% | 50.5% |
| Male Population | 47.6% | 50.3% | 49.5% |
| Median Age | 42.2 | 36.9 | 38.4 |
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| Population - 2010 | 20,770 | 109,608 | 309,327,143 |
| Population - 2000 | 20,784 | 107,006 | 285,036,114 |
| Population - 1990 | 25,925 | 99,567 | 251,960,433 |
| Pop. 2000 to Now | 3.7% | 5.2% | 15.6% |
| Pop. 1990 to Now | -16.9% | 13.0% | 30.8% |
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| Population Density | 1,398.4 | 3,468.8 | 93.4 |
| Land Area | 15.7 | 33.1 | 3,531,905.4 |
| Water Area | 1.2 | 1.9 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Portsmouth, NH | Manchester, NH | United States |
| Age 0 to 4 | 3.5% | 5.5% | 5.9% |
| Age 5 to 9 | 4.9% | 5.2% | 6.1% |
| Age 10 to 14 | 3.9% | 5.1% | 6.6% |
| Age 15 to 17 | 2.9% | 3.1% | 3.9% |
| Age 18 to 20 | 1.8% | 3.3% | 4.0% |
| Age 21 to 24 | 4.9% | 6.2% | 5.2% |
| Age 25 to 34 | 17.5% | 18.6% | 13.8% |
| Age 35 to 44 | 13.6% | 13.5% | 12.9% |
| Age 45 to 54 | 13.0% | 12.3% | 12.6% |
| Age 55 to 59 | 6.5% | 6.6% | 6.7% |
| Age 60 to 64 | 7.3% | 6.8% | 6.3% |
| Age 65 to 74 | 12.0% | 7.5% | 9.6% |
| Age 75 to 84 | 5.9% | 4.3% | 4.5% |
| Age 85 and over | 2.4% | 2.1% | 1.9% |
| space1 | | | |
| Race | | | |
| | Portsmouth, NH | Manchester, NH | United States |
| White | 87.3% | 74.9% | 59.4% |
| Black | 1.2% | 5.3% | 12.2% |
| Asian | 5.0% | 4.9% | 5.6% |
| Native American | 0.0% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 1.4% | 0.4% | 0.4% |
| Two or More Races | 2.9% | 3.5% | 3.2% |
| Hispanic | 2.3% | 11.0% | 18.4% |
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| Marriage & Family | | | |
| | Portsmouth, NH | Manchester, NH | United States |
| Married Population | 48.6% | 41.1% | 49.8% |
| Currently Married | 48.0% | 39.2% | 48.0% |
| Married but Separated | 0.7% | 1.8% | 1.8% |
| Single Population | 51.4% | 58.9% | 50.2% |
| Never Married | 33.7% | 39.2% | 33.8% |
| Divorced | 12.3% | 14.3% | 10.8% |
| Widowed | 5.4% | 5.4% | 5.6% |
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| Household Size | 2.05 | 2.32 | 2.60 |
| Households | 10,462 | 48,414 | 124,010,992 |
| Family Households | 5,348 | 25,967 | 80,755,759 |
| Married couple, w/children | 23.9% | 24.5% | 30.5% |
| Married couple, no children | 55.7% | 43.8% | 42.9% |
| Non Family Households | 5,114 | 22,447 | 43,255,233 |
| Single householder, w/children | 10.9% | 20.2% | 15.8% |
| Single householder, no children | 9.6% | 11.6% | 10.8% |