| | Santee, SC | Florence, SC | United States |
| Population | 1,029 | 39,816 | 329,725,481 |
| Female Population | 41.0% | 54.9% | 50.5% |
| Male Population | 59.0% | 45.1% | 49.5% |
| Median Age | 55 | 39.2 | 38.4 |
| space3 | | | |
| Population - 2010 | 963 | 37,928 | 309,327,143 |
| Population - 2000 | 740 | 30,248 | 285,036,114 |
| Population - 1990 | 638 | 29,813 | 251,960,433 |
| Pop. 2000 to Now | 20.1% | 27.2% | 15.6% |
| Pop. 1990 to Now | 39.3% | 29.0% | 30.8% |
| space4 | | | |
| Population Density | 487.7 | 1,789.4 | 93.4 |
| Land Area | 2.1 | 22.3 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Santee, SC | Florence, SC | United States |
| Age 0 to 4 | 3.7% | 6.5% | 5.9% |
| Age 5 to 9 | 5.2% | 6.2% | 6.1% |
| Age 10 to 14 | 6.2% | 7.7% | 6.6% |
| Age 15 to 17 | 3.6% | 4.1% | 3.9% |
| Age 18 to 20 | 5.4% | 2.8% | 4.0% |
| Age 21 to 24 | 1.9% | 3.8% | 5.2% |
| Age 25 to 34 | 8.6% | 13.9% | 13.8% |
| Age 35 to 44 | 6.3% | 12.5% | 12.9% |
| Age 45 to 54 | 9.2% | 11.9% | 12.6% |
| Age 55 to 59 | 3.4% | 6.2% | 6.7% |
| Age 60 to 64 | 16.2% | 5.8% | 6.3% |
| Age 65 to 74 | 18.3% | 11.7% | 9.6% |
| Age 75 to 84 | 4.5% | 5.3% | 4.5% |
| Age 85 and over | 7.5% | 1.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Santee, SC | Florence, SC | United States |
| White | 19.0% | 45.8% | 59.4% |
| Black | 81.1% | 47.4% | 12.2% |
| Asian | 0.0% | 2.6% | 5.6% |
| Native American | 0.0% | 0.4% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.0% | 0.5% | 0.4% |
| Two or More Races | 0.0% | 1.2% | 3.2% |
| Hispanic | 0.0% | 2.0% | 18.4% |
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| Marriage & Family | | | |
| | Santee, SC | Florence, SC | United States |
| Married Population | 26.1% | 47.9% | 49.8% |
| Currently Married | 21.7% | 44.7% | 48.0% |
| Married but Separated | 4.3% | 3.2% | 1.8% |
| Single Population | 73.9% | 52.1% | 50.2% |
| Never Married | 53.3% | 34.4% | 33.8% |
| Divorced | 12.0% | 10.9% | 10.8% |
| Widowed | 8.6% | 6.7% | 5.6% |
| space5 | | | |
| Household Size | 2.28 | 2.39 | 2.60 |
| Households | 432 | 16,412 | 124,010,992 |
| Family Households | 256 | 9,928 | 80,755,759 |
| Married couple, w/children | 0.0% | 27.9% | 30.5% |
| Married couple, no children | 30.1% | 38.8% | 42.9% |
| Non Family Households | 176 | 6,484 | 43,255,233 |
| Single householder, w/children | 30.5% | 22.0% | 15.8% |
| Single householder, no children | 39.5% | 11.2% | 10.8% |