| | Sikeston, MO | Jackson, MO | United States |
| Population | 16,054 | 15,272 | 329,725,481 |
| Female Population | 52.6% | 52.9% | 50.5% |
| Male Population | 47.4% | 47.1% | 49.5% |
| Median Age | 37.8 | 33.7 | 38.4 |
| space3 | | | |
| Population - 2010 | 16,347 | 13,805 | 309,327,143 |
| Population - 2000 | 16,992 | 11,947 | 285,036,114 |
| Population - 1990 | 17,641 | 9,256 | 251,960,433 |
| Pop. 2000 to Now | -6.0% | 23.0% | 15.6% |
| Pop. 1990 to Now | -9.5% | 58.8% | 30.8% |
| space4 | | | |
| Population Density | 918.9 | 1,436.4 | 93.4 |
| Land Area | 17.5 | 10.6 | 3,531,905.4 |
| Water Area | 0.2 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Sikeston, MO | Jackson, MO | United States |
| Age 0 to 4 | 7.6% | 6.4% | 5.9% |
| Age 5 to 9 | 7.5% | 7.2% | 6.1% |
| Age 10 to 14 | 5.8% | 8.2% | 6.6% |
| Age 15 to 17 | 3.5% | 5.1% | 3.9% |
| Age 18 to 20 | 2.1% | 2.6% | 4.0% |
| Age 21 to 24 | 4.4% | 6.8% | 5.2% |
| Age 25 to 34 | 15.4% | 15.1% | 13.8% |
| Age 35 to 44 | 9.8% | 13.2% | 12.9% |
| Age 45 to 54 | 9.4% | 10.9% | 12.6% |
| Age 55 to 59 | 6.5% | 3.9% | 6.7% |
| Age 60 to 64 | 5.6% | 5.9% | 6.3% |
| Age 65 to 74 | 10.7% | 8.5% | 9.6% |
| Age 75 to 84 | 9.0% | 3.7% | 4.5% |
| Age 85 and over | 2.5% | 2.6% | 1.9% |
| space1 | | | |
| Race | | | |
| | Sikeston, MO | Jackson, MO | United States |
| White | 66.5% | 91.7% | 59.4% |
| Black | 24.2% | 1.5% | 12.2% |
| Asian | 0.8% | 0.3% | 5.6% |
| Native American | 0.0% | 0.3% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.0% | 0.3% | 0.4% |
| Two or More Races | 5.4% | 3.6% | 3.2% |
| Hispanic | 3.0% | 2.2% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Sikeston, MO | Jackson, MO | United States |
| Married Population | 47.9% | 54.1% | 49.8% |
| Currently Married | 46.0% | 52.7% | 48.0% |
| Married but Separated | 1.9% | 1.4% | 1.8% |
| Single Population | 52.1% | 45.9% | 50.2% |
| Never Married | 30.7% | 26.8% | 33.8% |
| Divorced | 12.6% | 12.3% | 10.8% |
| Widowed | 8.8% | 6.7% | 5.6% |
| space5 | | | |
| Household Size | 2.30 | 2.62 | 2.60 |
| Households | 6,846 | 5,700 | 124,010,992 |
| Family Households | 4,199 | 4,106 | 80,755,759 |
| Married couple, w/children | 25.0% | 36.6% | 30.5% |
| Married couple, no children | 41.6% | 39.1% | 42.9% |
| Non Family Households | 2,647 | 1,594 | 43,255,233 |
| Single householder, w/children | 24.8% | 14.7% | 15.8% |
| Single householder, no children | 8.6% | 9.6% | 10.8% |