| | St. Matthews, SC | Hopkins, SC | United States |
| Population | 2,038 | 1,757 | 329,725,481 |
| Female Population | 52.9% | 47.2% | 50.5% |
| Male Population | 47.2% | 52.8% | 49.5% |
| Median Age | 41.8 | 53.2 | 38.4 |
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| Population - 2010 | 2,014 | 3,061 | 309,327,143 |
| Population - 2000 | 2,107 | 3,000 | 285,036,114 |
| Population - 1990 | 2,345 | 3,130 | 251,960,433 |
| Pop. 2000 to Now | -9.7% | 3.9% | 15.6% |
| Pop. 1990 to Now | -18.9% | -0.4% | 30.8% |
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| Population Density | 1,060.4 | 106.4 | 93.4 |
| Land Area | 1.9 | 16.5 | 3,531,905.4 |
| Water Area | 0.0 | 0.0 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | St. Matthews, SC | Hopkins, SC | United States |
| Age 0 to 4 | 7.4% | 2.4% | 5.9% |
| Age 5 to 9 | 3.8% | 2.7% | 6.1% |
| Age 10 to 14 | 5.9% | 0.0% | 6.6% |
| Age 15 to 17 | 2.3% | 1.9% | 3.9% |
| Age 18 to 20 | 2.0% | 1.8% | 4.0% |
| Age 21 to 24 | 5.4% | 5.4% | 5.2% |
| Age 25 to 34 | 15.1% | 7.5% | 13.8% |
| Age 35 to 44 | 12.4% | 9.8% | 12.9% |
| Age 45 to 54 | 5.3% | 19.1% | 12.6% |
| Age 55 to 59 | 6.1% | 13.9% | 6.7% |
| Age 60 to 64 | 7.2% | 7.9% | 6.3% |
| Age 65 to 74 | 15.8% | 15.6% | 9.6% |
| Age 75 to 84 | 9.1% | 11.8% | 4.5% |
| Age 85 and over | 2.3% | 0.0% | 1.9% |
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| Race | | | |
| | St. Matthews, SC | Hopkins, SC | United States |
| White | 38.5% | 12.7% | 59.4% |
| Black | 60.0% | 86.5% | 12.2% |
| Asian | 0.3% | 0.0% | 5.6% |
| Native American | 0.2% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 0.0% | 0.8% | 3.2% |
| Hispanic | 0.8% | 0.0% | 18.4% |
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| Marriage & Family | | | |
| | St. Matthews, SC | Hopkins, SC | United States |
| Married Population | 34.0% | 45.4% | 49.8% |
| Currently Married | 30.4% | 39.9% | 48.0% |
| Married but Separated | 3.6% | 5.6% | 1.8% |
| Single Population | 66.0% | 54.6% | 50.2% |
| Never Married | 42.9% | 28.9% | 33.8% |
| Divorced | 8.1% | 13.1% | 10.8% |
| Widowed | 15.0% | 12.5% | 5.6% |
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| Household Size | 2.42 | 2.11 | 2.60 |
| Households | 792 | 827 | 124,010,992 |
| Family Households | 477 | 433 | 80,755,759 |
| Married couple, w/children | 17.2% | 8.1% | 30.5% |
| Married couple, no children | 31.7% | 55.4% | 42.9% |
| Non Family Households | 315 | 394 | 43,255,233 |
| Single householder, w/children | 23.1% | 14.1% | 15.8% |
| Single householder, no children | 28.1% | 22.4% | 10.8% |