| | Vermillion, SD | Wayne, NE | United States |
| Population | 11,506 | 5,847 | 329,725,481 |
| Female Population | 51.1% | 51.3% | 50.5% |
| Male Population | 48.9% | 48.7% | 49.5% |
| Median Age | 23 | 22.6 | 38.4 |
| space3 | | | |
| Population - 2010 | 10,554 | 5,681 | 309,327,143 |
| Population - 2000 | 9,765 | 5,583 | 285,036,114 |
| Population - 1990 | 10,034 | 5,142 | 251,960,433 |
| Pop. 2000 to Now | 13.0% | 3.1% | 15.6% |
| Pop. 1990 to Now | 10.0% | 12.0% | 30.8% |
| space4 | | | |
| Population Density | 2,519.4 | 2,080.8 | 93.4 |
| Land Area | 4.6 | 2.8 | 3,531,905.4 |
| Water Area | 0.0 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Vermillion, SD | Wayne, NE | United States |
| Age 0 to 4 | 5.3% | 3.8% | 5.9% |
| Age 5 to 9 | 4.1% | 3.5% | 6.1% |
| Age 10 to 14 | 5.6% | 7.5% | 6.6% |
| Age 15 to 17 | 1.7% | 3.0% | 3.9% |
| Age 18 to 20 | 23.2% | 24.5% | 4.0% |
| Age 21 to 24 | 16.9% | 11.6% | 5.2% |
| Age 25 to 34 | 12.8% | 7.2% | 13.8% |
| Age 35 to 44 | 8.1% | 9.9% | 12.9% |
| Age 45 to 54 | 5.6% | 8.2% | 12.6% |
| Age 55 to 59 | 1.8% | 5.5% | 6.7% |
| Age 60 to 64 | 5.7% | 2.9% | 6.3% |
| Age 65 to 74 | 5.9% | 4.6% | 9.6% |
| Age 75 to 84 | 1.7% | 4.7% | 4.5% |
| Age 85 and over | 1.4% | 3.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Vermillion, SD | Wayne, NE | United States |
| White | 83.8% | 85.5% | 59.4% |
| Black | 2.0% | 1.6% | 12.2% |
| Asian | 3.6% | 0.9% | 5.6% |
| Native American | 4.0% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.5% | 0.2% | 0.4% |
| Two or More Races | 2.3% | 2.5% | 3.2% |
| Hispanic | 3.6% | 9.2% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Vermillion, SD | Wayne, NE | United States |
| Married Population | 30.2% | 35.9% | 49.8% |
| Currently Married | 30.2% | 35.1% | 48.0% |
| Married but Separated | 0.0% | 0.8% | 1.8% |
| Single Population | 69.8% | 64.1% | 50.2% |
| Never Married | 61.2% | 51.7% | 33.8% |
| Divorced | 5.4% | 6.9% | 10.8% |
| Widowed | 3.2% | 5.4% | 5.6% |
| space5 | | | |
| Household Size | 2.31 | 2.15 | 2.60 |
| Households | 3,964 | 2,075 | 124,010,992 |
| Family Households | 1,734 | 1,048 | 80,755,759 |
| Married couple, w/children | 28.8% | 39.4% | 30.5% |
| Married couple, no children | 52.9% | 44.4% | 42.9% |
| Non Family Households | 2,230 | 1,027 | 43,255,233 |
| Single householder, w/children | 15.4% | 6.3% | 15.8% |
| Single householder, no children | 2.9% | 9.9% | 10.8% |