| | Wessington, SD | Chamberlain, SD | United States |
| Population | 220 | 2,400 | 329,725,481 |
| Female Population | 52.7% | 50.5% | 50.5% |
| Male Population | 47.3% | 49.5% | 49.5% |
| Median Age | 38.8 | 38.1 | 38.4 |
| space3 | | | |
| Population - 2010 | 168 | 2,389 | 309,327,143 |
| Population - 2000 | 248 | 2,338 | 285,036,114 |
| Population - 1990 | 265 | 2,347 | 251,960,433 |
| Pop. 2000 to Now | -27.8% | 0.4% | 15.6% |
| Pop. 1990 to Now | -32.5% | 0.0% | 30.8% |
| space4 | | | |
| Population Density | 582.0 | 369.7 | 93.4 |
| Land Area | 0.4 | 6.5 | 3,531,905.4 |
| Water Area | 0.0 | 1.2 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Wessington, SD | Chamberlain, SD | United States |
| Age 0 to 4 | 4.5% | 6.5% | 5.9% |
| Age 5 to 9 | 10.9% | 6.3% | 6.1% |
| Age 10 to 14 | 10.0% | 9.5% | 6.6% |
| Age 15 to 17 | 1.4% | 5.1% | 3.9% |
| Age 18 to 20 | 0.0% | 1.8% | 4.0% |
| Age 21 to 24 | 0.5% | 5.3% | 5.2% |
| Age 25 to 34 | 17.3% | 11.7% | 13.8% |
| Age 35 to 44 | 11.8% | 13.3% | 12.9% |
| Age 45 to 54 | 6.8% | 8.3% | 12.6% |
| Age 55 to 59 | 8.2% | 6.8% | 6.7% |
| Age 60 to 64 | 3.2% | 7.7% | 6.3% |
| Age 65 to 74 | 15.9% | 8.9% | 9.6% |
| Age 75 to 84 | 2.7% | 5.0% | 4.5% |
| Age 85 and over | 6.8% | 3.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Wessington, SD | Chamberlain, SD | United States |
| White | 98.6% | 65.9% | 59.4% |
| Black | 0.0% | 2.5% | 12.2% |
| Asian | 0.0% | 0.9% | 5.6% |
| Native American | 0.0% | 27.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 0.5% | 2.9% | 3.2% |
| Hispanic | 0.9% | 0.7% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Wessington, SD | Chamberlain, SD | United States |
| Married Population | 55.5% | 43.2% | 49.8% |
| Currently Married | 52.4% | 42.4% | 48.0% |
| Married but Separated | 3.0% | 0.8% | 1.8% |
| Single Population | 44.5% | 56.8% | 50.2% |
| Never Married | 15.2% | 34.2% | 33.8% |
| Divorced | 14.0% | 15.2% | 10.8% |
| Widowed | 15.2% | 7.5% | 5.6% |
| space5 | | | |
| Household Size | 2.14 | 2.46 | 2.60 |
| Households | 103 | 847 | 124,010,992 |
| Family Households | 59 | 462 | 80,755,759 |
| Married couple, w/children | 32.2% | 28.8% | 30.5% |
| Married couple, no children | 40.7% | 51.9% | 42.9% |
| Non Family Households | 44 | 385 | 43,255,233 |
| Single householder, w/children | 20.3% | 16.7% | 15.8% |
| Single householder, no children | 6.8% | 2.6% | 10.8% |