| | Wise, VA | Boone, NC | United States |
| Population | 2,976 | 18,055 | 329,725,481 |
| Female Population | 45.8% | 54.2% | 50.5% |
| Male Population | 54.2% | 45.8% | 49.5% |
| Median Age | 41.1 | 20.9 | 38.4 |
| space3 | | | |
| Population - 2010 | 3,238 | 17,094 | 309,327,143 |
| Population - 2000 | 3,255 | 13,472 | 285,036,114 |
| Population - 1990 | 3,193 | 12,915 | 251,960,433 |
| Pop. 2000 to Now | -11.4% | 48.5% | 15.6% |
| Pop. 1990 to Now | -9.7% | 54.9% | 30.8% |
| space4 | | | |
| Population Density | 982.5 | 2,862.2 | 93.4 |
| Land Area | 3.0 | 6.3 | 3,531,905.4 |
| Water Area | 0.0 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Wise, VA | Boone, NC | United States |
| Age 0 to 4 | 4.7% | 1.1% | 5.9% |
| Age 5 to 9 | 4.3% | 1.4% | 6.1% |
| Age 10 to 14 | 5.0% | 2.9% | 6.6% |
| Age 15 to 17 | 2.2% | 1.0% | 3.9% |
| Age 18 to 20 | 4.0% | 44.8% | 4.0% |
| Age 21 to 24 | 8.6% | 19.4% | 5.2% |
| Age 25 to 34 | 17.6% | 8.5% | 13.8% |
| Age 35 to 44 | 6.3% | 6.4% | 12.9% |
| Age 45 to 54 | 13.5% | 4.2% | 12.6% |
| Age 55 to 59 | 8.0% | 2.0% | 6.7% |
| Age 60 to 64 | 6.3% | 3.1% | 6.3% |
| Age 65 to 74 | 14.9% | 2.3% | 9.6% |
| Age 75 to 84 | 2.4% | 1.7% | 4.5% |
| Age 85 and over | 2.1% | 1.1% | 1.9% |
| space1 | | | |
| Race | | | |
| | Wise, VA | Boone, NC | United States |
| White | 91.5% | 87.4% | 59.4% |
| Black | 4.3% | 3.1% | 12.2% |
| Asian | 0.6% | 1.7% | 5.6% |
| Native American | 0.0% | 0.4% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 2.3% | 1.8% | 3.2% |
| Hispanic | 1.3% | 5.6% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Wise, VA | Boone, NC | United States |
| Married Population | 43.5% | 14.0% | 49.8% |
| Currently Married | 42.7% | 12.4% | 48.0% |
| Married but Separated | 0.7% | 1.6% | 1.8% |
| Single Population | 56.5% | 86.0% | 50.2% |
| Never Married | 33.2% | 79.2% | 33.8% |
| Divorced | 17.9% | 4.2% | 10.8% |
| Widowed | 5.5% | 2.6% | 5.6% |
| space5 | | | |
| Household Size | 2.22 | 2.36 | 2.60 |
| Households | 1,335 | 5,304 | 124,010,992 |
| Family Households | 718 | 1,307 | 80,755,759 |
| Married couple, w/children | 21.6% | 33.7% | 30.5% |
| Married couple, no children | 49.9% | 38.9% | 42.9% |
| Non Family Households | 617 | 3,997 | 43,255,233 |
| Single householder, w/children | 20.3% | 17.0% | 15.8% |
| Single householder, no children | 8.2% | 10.4% | 10.8% |