Cairo, Missouri is a small town located in the Bootheel region of the state. It has a population of 745 according to the 2020 U.S. Census. Despite its size, Cairo has been ranked highly in several BestPlaces lists. For example, it was ranked as one of the “Top 10 Safest Small Towns in Missouri” by HomeSnacks for 2020 based on data from both public and private sources such as the FBI Uniform Crime Report and Homefacts. Cairo also scored high marks on WalletHub's \"2020’s Best Small Cities in America\" list coming in at #16 out of 1,268 cities across all 50 states. According to the study, Cairo earned its place due to its low cost of living and great quality of life measures such as access to parks, housing affordability, and school system quality. Lastly, Cairo was included as part of USA Today's \"10 best small towns to visit in Missouri\" list for 2021 highlighting its easy access to outdoor recreation and unique local attractions like the Bootheel Youth Museum
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