Cherokee County, NC borders Graham near Murphy metropolitan centre thus giving us a 2020 estimated population standing at 27,746 making it one of least populated counties located in this region overall. Its county seat is Murphy with other towns including Andrews & Marble - Murphy itself corresponds out to Cherokee’s biggest town aside from recognized county seat. This area had been created out of Macon and Swain Counties back in 1839 when local citizens petitioned for new administrative boundaries - posthumously named after Cherokee Nation which was the largest nation within Five Civilized Tribes of Native American people during reigns both George III & King George IV .