Holmes County, OH neighbors Wayne near Millersburg metropolitan centre yielding a 2020 estimated census population standing at 43,873 making it the 22nd least populous county located hereabouts. Its county seat is Millersburg with other towns include Berlin & Walnut Creek-Millersburg itself corresponds out to Holmes’s biggesttown aside from acknowledged country seat. This area had been established from Coshocton and Tuscarawas Counties back in 1824 when local residents petitioned for new administrative boundaries - posthumously named after Founding Father Oliver Holmes Jr govern through period James Monroe .