| | Barbourville, KY | Prestonsburg, KY | United States |
| Population | 3,048 | 4,099 | 329,725,481 |
| Female Population | 67.2% | 48.0% | 50.5% |
| Male Population | 32.8% | 52.0% | 49.5% |
| Median Age | 42.2 | 34.1 | 38.4 |
| space3 | | | |
| Population - 2010 | 3,172 | 3,845 | 309,327,143 |
| Population - 2000 | 3,589 | 3,612 | 285,036,114 |
| Population - 1990 | 3,658 | 3,558 | 251,960,433 |
| Pop. 2000 to Now | -17.1% | -4.2% | 15.6% |
| Pop. 1990 to Now | -18.7% | -2.8% | 30.8% |
| space4 | | | |
| Population Density | 1,148.9 | 283.2 | 93.4 |
| Land Area | 2.7 | 14.5 | 3,531,905.4 |
| Water Area | 0.1 | 0.2 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Barbourville, KY | Prestonsburg, KY | United States |
| Age 0 to 4 | 0.3% | 7.3% | 5.9% |
| Age 5 to 9 | 0.3% | 6.8% | 6.1% |
| Age 10 to 14 | 6.5% | 5.3% | 6.6% |
| Age 15 to 17 | 0.8% | 2.9% | 3.9% |
| Age 18 to 20 | 10.5% | 11.3% | 4.0% |
| Age 21 to 24 | 9.1% | 4.9% | 5.2% |
| Age 25 to 34 | 17.4% | 12.8% | 13.8% |
| Age 35 to 44 | 6.7% | 12.3% | 12.9% |
| Age 45 to 54 | 8.1% | 9.2% | 12.6% |
| Age 55 to 59 | 3.8% | 4.0% | 6.7% |
| Age 60 to 64 | 14.5% | 4.6% | 6.3% |
| Age 65 to 74 | 5.3% | 11.2% | 9.6% |
| Age 75 to 84 | 7.5% | 3.5% | 4.5% |
| Age 85 and over | 9.1% | 4.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Barbourville, KY | Prestonsburg, KY | United States |
| White | 95.5% | 93.7% | 59.4% |
| Black | 2.7% | 3.7% | 12.2% |
| Asian | 0.0% | 0.7% | 5.6% |
| Native American | 1.2% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 0.1% | 1.7% | 3.2% |
| Hispanic | 0.5% | 0.2% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Barbourville, KY | Prestonsburg, KY | United States |
| Married Population | 31.8% | 48.4% | 49.8% |
| Currently Married | 23.9% | 44.2% | 48.0% |
| Married but Separated | 7.9% | 4.2% | 1.8% |
| Single Population | 68.2% | 51.6% | 50.2% |
| Never Married | 37.2% | 31.0% | 33.8% |
| Divorced | 20.9% | 12.1% | 10.8% |
| Widowed | 10.1% | 8.6% | 5.6% |
| space5 | | | |
| Household Size | 2.49 | 2.43 | 2.60 |
| Households | 1,005 | 1,434 | 124,010,992 |
| Family Households | 422 | 960 | 80,755,759 |
| Married couple, w/children | 5.5% | 30.1% | 30.5% |
| Married couple, no children | 55.2% | 42.1% | 42.9% |
| Non Family Households | 583 | 474 | 43,255,233 |
| Single householder, w/children | 35.8% | 22.3% | 15.8% |
| Single householder, no children | 3.6% | 5.5% | 10.8% |