| | Cherokee, NC | Picayune, MS | United States |
| Population | 2,059 | 11,777 | 329,725,481 |
| Female Population | 47.0% | 53.4% | 50.5% |
| Male Population | 53.0% | 46.6% | 49.5% |
| Median Age | 45.3 | 39 | 38.4 |
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| Population - 2010 | 3,182 | 11,631 | 309,327,143 |
| Population - 2000 | 2,012 | 10,535 | 285,036,114 |
| Population - 1990 | 1,721 | 10,633 | 251,960,433 |
| Pop. 2000 to Now | 22.2% | 3.3% | 15.6% |
| Pop. 1990 to Now | 42.9% | 2.4% | 30.8% |
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| Population Density | 170.6 | 652.9 | 93.4 |
| Land Area | 12.1 | 18.0 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Cherokee, NC | Picayune, MS | United States |
| Age 0 to 4 | 6.7% | 6.9% | 5.9% |
| Age 5 to 9 | 3.8% | 7.7% | 6.1% |
| Age 10 to 14 | 2.9% | 8.2% | 6.6% |
| Age 15 to 17 | 2.7% | 3.2% | 3.9% |
| Age 18 to 20 | 7.5% | 2.8% | 4.0% |
| Age 21 to 24 | 6.3% | 4.8% | 5.2% |
| Age 25 to 34 | 9.0% | 12.5% | 13.8% |
| Age 35 to 44 | 10.5% | 10.9% | 12.9% |
| Age 45 to 54 | 13.0% | 12.8% | 12.6% |
| Age 55 to 59 | 8.1% | 6.2% | 6.7% |
| Age 60 to 64 | 4.7% | 5.9% | 6.3% |
| Age 65 to 74 | 15.0% | 10.6% | 9.6% |
| Age 75 to 84 | 8.6% | 5.4% | 4.5% |
| Age 85 and over | 1.3% | 2.0% | 1.9% |
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| Race | | | |
| | Cherokee, NC | Picayune, MS | United States |
| White | 10.1% | 54.2% | 59.4% |
| Black | 1.7% | 37.7% | 12.2% |
| Asian | 1.3% | 0.3% | 5.6% |
| Native American | 82.3% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.5% | 0.4% |
| Two or More Races | 3.3% | 4.4% | 3.2% |
| Hispanic | 1.4% | 2.8% | 18.4% |
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| Marriage & Family | | | |
| | Cherokee, NC | Picayune, MS | United States |
| Married Population | 43.8% | 42.5% | 49.8% |
| Currently Married | 42.7% | 37.4% | 48.0% |
| Married but Separated | 1.2% | 5.1% | 1.8% |
| Single Population | 56.2% | 57.5% | 50.2% |
| Never Married | 29.7% | 35.8% | 33.8% |
| Divorced | 18.8% | 13.7% | 10.8% |
| Widowed | 7.7% | 8.0% | 5.6% |
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| Household Size | 2.32 | 2.66 | 2.60 |
| Households | 881 | 4,391 | 124,010,992 |
| Family Households | 588 | 2,831 | 80,755,759 |
| Married couple, w/children | 19.4% | 16.6% | 30.5% |
| Married couple, no children | 40.3% | 32.1% | 42.9% |
| Non Family Households | 293 | 1,560 | 43,255,233 |
| Single householder, w/children | 30.3% | 34.3% | 15.8% |
| Single householder, no children | 10.0% | 17.0% | 10.8% |