| | De Soto, MO | Lancaster, CA | United States |
| Population | 6,429 | 171,820 | 329,725,481 |
| Female Population | 54.1% | 49.3% | 50.5% |
| Male Population | 45.9% | 50.7% | 49.5% |
| Median Age | 35 | 33.3 | 38.4 |
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| Population - 2010 | 6,387 | 156,897 | 309,327,143 |
| Population - 2000 | 6,375 | 118,718 | 285,036,114 |
| Population - 1990 | 5,993 | 97,291 | 251,960,433 |
| Pop. 2000 to Now | -0.6% | 31.3% | 15.6% |
| Pop. 1990 to Now | 5.8% | 60.2% | 30.8% |
| space4 | | | |
| Population Density | 1,494.8 | 1,822.4 | 93.4 |
| Land Area | 4.3 | 94.3 | 3,531,905.4 |
| Water Area | 0.0 | 0.3 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | De Soto, MO | Lancaster, CA | United States |
| Age 0 to 4 | 7.6% | 6.9% | 5.9% |
| Age 5 to 9 | 7.0% | 7.2% | 6.1% |
| Age 10 to 14 | 9.9% | 9.5% | 6.6% |
| Age 15 to 17 | 5.5% | 4.9% | 3.9% |
| Age 18 to 20 | 2.4% | 4.5% | 4.0% |
| Age 21 to 24 | 6.0% | 4.8% | 5.2% |
| Age 25 to 34 | 11.8% | 14.4% | 13.8% |
| Age 35 to 44 | 13.3% | 13.8% | 12.9% |
| Age 45 to 54 | 9.8% | 12.0% | 12.6% |
| Age 55 to 59 | 4.2% | 6.3% | 6.7% |
| Age 60 to 64 | 6.1% | 5.3% | 6.3% |
| Age 65 to 74 | 10.8% | 6.6% | 9.6% |
| Age 75 to 84 | 4.6% | 3.0% | 4.5% |
| Age 85 and over | 1.2% | 1.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | De Soto, MO | Lancaster, CA | United States |
| White | 84.9% | 27.3% | 59.4% |
| Black | 0.8% | 20.0% | 12.2% |
| Asian | 0.3% | 3.9% | 5.6% |
| Native American | 0.2% | 0.4% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.1% | 0.5% | 0.4% |
| Two or More Races | 12.5% | 3.1% | 3.2% |
| Hispanic | 1.1% | 44.8% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | De Soto, MO | Lancaster, CA | United States |
| Married Population | 38.8% | 43.8% | 49.8% |
| Currently Married | 38.2% | 41.5% | 48.0% |
| Married but Separated | 0.6% | 2.3% | 1.8% |
| Single Population | 61.2% | 56.2% | 50.2% |
| Never Married | 30.0% | 43.2% | 33.8% |
| Divorced | 22.7% | 8.7% | 10.8% |
| Widowed | 8.5% | 4.2% | 5.6% |
| space5 | | | |
| Household Size | 2.52 | 3.15 | 2.60 |
| Households | 2,496 | 52,448 | 124,010,992 |
| Family Households | 1,515 | 38,256 | 80,755,759 |
| Married couple, w/children | 26.5% | 33.9% | 30.5% |
| Married couple, no children | 31.8% | 29.9% | 42.9% |
| Non Family Households | 981 | 14,192 | 43,255,233 |
| Single householder, w/children | 35.1% | 22.3% | 15.8% |
| Single householder, no children | 6.6% | 14.0% | 10.8% |