| | East Prairie, MO | Charleston, MO | United States |
| Population | 3,018 | 5,184 | 329,725,481 |
| Female Population | 53.0% | 35.8% | 50.5% |
| Male Population | 47.0% | 64.2% | 49.5% |
| Median Age | 46.3 | 38.6 | 38.4 |
| space3 | | | |
| Population - 2010 | 3,118 | 5,899 | 309,327,143 |
| Population - 2000 | 3,227 | 4,732 | 285,036,114 |
| Population - 1990 | 3,416 | 5,085 | 251,960,433 |
| Pop. 2000 to Now | -9.4% | 6.0% | 15.6% |
| Pop. 1990 to Now | -14.4% | -1.4% | 30.8% |
| space4 | | | |
| Population Density | 2,334.1 | 1,080.9 | 93.4 |
| Land Area | 1.3 | 4.8 | 3,531,905.4 |
| Water Area | 0.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | East Prairie, MO | Charleston, MO | United States |
| Age 0 to 4 | 2.8% | 3.6% | 5.9% |
| Age 5 to 9 | 4.7% | 6.7% | 6.1% |
| Age 10 to 14 | 8.6% | 5.6% | 6.6% |
| Age 15 to 17 | 7.1% | 3.7% | 3.9% |
| Age 18 to 20 | 4.2% | 2.8% | 4.0% |
| Age 21 to 24 | 3.5% | 5.6% | 5.2% |
| Age 25 to 34 | 8.8% | 16.7% | 13.8% |
| Age 35 to 44 | 8.7% | 15.7% | 12.9% |
| Age 45 to 54 | 14.8% | 13.4% | 12.6% |
| Age 55 to 59 | 5.3% | 8.4% | 6.7% |
| Age 60 to 64 | 7.4% | 3.2% | 6.3% |
| Age 65 to 74 | 14.0% | 9.7% | 9.6% |
| Age 75 to 84 | 7.7% | 2.9% | 4.5% |
| Age 85 and over | 2.2% | 1.9% | 1.9% |
| space1 | | | |
| Race | | | |
| | East Prairie, MO | Charleston, MO | United States |
| White | 87.4% | 41.1% | 59.4% |
| Black | 3.7% | 55.8% | 12.2% |
| Asian | 0.0% | 0.0% | 5.6% |
| Native American | 0.0% | 0.8% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 8.8% | 1.3% | 3.2% |
| Hispanic | 0.0% | 1.0% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | East Prairie, MO | Charleston, MO | United States |
| Married Population | 43.1% | 34.5% | 49.8% |
| Currently Married | 39.6% | 32.1% | 48.0% |
| Married but Separated | 3.5% | 2.3% | 1.8% |
| Single Population | 56.9% | 65.5% | 50.2% |
| Never Married | 22.1% | 46.6% | 33.8% |
| Divorced | 26.0% | 13.0% | 10.8% |
| Widowed | 8.7% | 5.9% | 5.6% |
| space5 | | | |
| Household Size | 2.21 | 2.60 | 2.60 |
| Households | 1,349 | 1,432 | 124,010,992 |
| Family Households | 852 | 923 | 80,755,759 |
| Married couple, w/children | 19.2% | 31.1% | 30.5% |
| Married couple, no children | 35.2% | 38.4% | 42.9% |
| Non Family Households | 497 | 509 | 43,255,233 |
| Single householder, w/children | 34.5% | 17.7% | 15.8% |
| Single householder, no children | 11.0% | 12.9% | 10.8% |