| | Edwardsville, IL | East St. Louis, IL | United States |
| Population | 25,236 | 19,437 | 329,725,481 |
| Female Population | 52.3% | 57.0% | 50.5% |
| Male Population | 47.7% | 43.1% | 49.5% |
| Median Age | 28.7 | 42.7 | 38.4 |
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| Population - 2010 | 24,407 | 26,911 | 309,327,143 |
| Population - 2000 | 21,491 | 31,542 | 285,036,114 |
| Population - 1990 | 14,579 | 40,944 | 251,960,433 |
| Pop. 2000 to Now | 17.2% | -18.3% | 15.6% |
| Pop. 1990 to Now | 72.8% | -37.1% | 30.8% |
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| Population Density | 1,279.0 | 1,397.1 | 93.4 |
| Land Area | 19.7 | 13.9 | 3,531,905.4 |
| Water Area | 0.6 | 0.4 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Edwardsville, IL | East St. Louis, IL | United States |
| Age 0 to 4 | 5.8% | 4.8% | 5.9% |
| Age 5 to 9 | 5.2% | 4.6% | 6.1% |
| Age 10 to 14 | 5.7% | 6.2% | 6.6% |
| Age 15 to 17 | 3.8% | 4.0% | 3.9% |
| Age 18 to 20 | 15.3% | 3.7% | 4.0% |
| Age 21 to 24 | 9.9% | 4.2% | 5.2% |
| Age 25 to 34 | 11.6% | 15.0% | 13.8% |
| Age 35 to 44 | 10.8% | 10.5% | 12.9% |
| Age 45 to 54 | 12.1% | 11.9% | 12.6% |
| Age 55 to 59 | 4.5% | 5.1% | 6.7% |
| Age 60 to 64 | 4.9% | 8.9% | 6.3% |
| Age 65 to 74 | 6.5% | 13.0% | 9.6% |
| Age 75 to 84 | 2.6% | 6.7% | 4.5% |
| Age 85 and over | 1.4% | 1.5% | 1.9% |
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| Race | | | |
| | Edwardsville, IL | East St. Louis, IL | United States |
| White | 83.5% | 1.7% | 59.4% |
| Black | 8.6% | 95.2% | 12.2% |
| Asian | 2.5% | 0.9% | 5.6% |
| Native American | 0.3% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.1% | 0.1% | 0.4% |
| Two or More Races | 2.8% | 0.9% | 3.2% |
| Hispanic | 2.3% | 1.2% | 18.4% |
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| Marriage & Family | | | |
| | Edwardsville, IL | East St. Louis, IL | United States |
| Married Population | 42.9% | 19.9% | 49.8% |
| Currently Married | 42.0% | 15.9% | 48.0% |
| Married but Separated | 0.9% | 4.0% | 1.8% |
| Single Population | 57.1% | 80.1% | 50.2% |
| Never Married | 45.3% | 54.7% | 33.8% |
| Divorced | 8.7% | 14.3% | 10.8% |
| Widowed | 3.0% | 11.1% | 5.6% |
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| Household Size | 2.57 | 2.53 | 2.60 |
| Households | 8,552 | 7,644 | 124,010,992 |
| Family Households | 5,214 | 3,723 | 80,755,759 |
| Married couple, w/children | 44.3% | 5.8% | 30.5% |
| Married couple, no children | 38.2% | 23.5% | 42.9% |
| Non Family Households | 3,338 | 3,921 | 43,255,233 |
| Single householder, w/children | 9.4% | 39.1% | 15.8% |
| Single householder, no children | 8.2% | 31.6% | 10.8% |