| | Grand Island, NE | Syracuse, NY | United States |
| Population | 52,755 | 146,781 | 329,725,481 |
| Female Population | 48.9% | 52.0% | 50.5% |
| Male Population | 51.2% | 48.0% | 49.5% |
| Median Age | 34.9 | 31.7 | 38.4 |
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| Population - 2010 | 48,841 | 145,116 | 309,327,143 |
| Population - 2000 | 42,940 | 147,306 | 285,036,114 |
| Population - 1990 | 39,386 | 163,860 | 251,960,433 |
| Pop. 2000 to Now | 18.8% | -4.1% | 15.6% |
| Pop. 1990 to Now | 29.5% | -13.8% | 30.8% |
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| Population Density | 1,773.5 | 5,864.2 | 93.4 |
| Land Area | 29.7 | 25.0 | 3,531,905.4 |
| Water Area | 0.2 | 0.6 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Grand Island, NE | Syracuse, NY | United States |
| Age 0 to 4 | 7.7% | 6.1% | 5.9% |
| Age 5 to 9 | 7.6% | 5.8% | 6.1% |
| Age 10 to 14 | 8.7% | 6.1% | 6.6% |
| Age 15 to 17 | 4.5% | 3.6% | 3.9% |
| Age 18 to 20 | 3.4% | 9.9% | 4.0% |
| Age 21 to 24 | 4.8% | 7.2% | 5.2% |
| Age 25 to 34 | 13.5% | 16.0% | 13.8% |
| Age 35 to 44 | 12.8% | 10.9% | 12.9% |
| Age 45 to 54 | 11.4% | 10.7% | 12.6% |
| Age 55 to 59 | 6.1% | 5.3% | 6.7% |
| Age 60 to 64 | 5.1% | 5.8% | 6.3% |
| Age 65 to 74 | 8.4% | 7.8% | 9.6% |
| Age 75 to 84 | 3.7% | 3.1% | 4.5% |
| Age 85 and over | 2.4% | 1.7% | 1.9% |
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| Race | | | |
| | Grand Island, NE | Syracuse, NY | United States |
| White | 60.5% | 49.4% | 59.4% |
| Black | 3.4% | 27.5% | 12.2% |
| Asian | 1.3% | 7.0% | 5.6% |
| Native American | 0.4% | 0.8% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.2% | 0.5% | 0.4% |
| Two or More Races | 1.1% | 5.2% | 3.2% |
| Hispanic | 33.0% | 9.5% | 18.4% |
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| Marriage & Family | | | |
| | Grand Island, NE | Syracuse, NY | United States |
| Married Population | 51.1% | 29.4% | 49.8% |
| Currently Married | 49.6% | 26.5% | 48.0% |
| Married but Separated | 1.5% | 2.9% | 1.8% |
| Single Population | 48.9% | 70.6% | 50.2% |
| Never Married | 32.1% | 54.4% | 33.8% |
| Divorced | 11.5% | 11.2% | 10.8% |
| Widowed | 5.3% | 5.0% | 5.6% |
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| Household Size | 2.61 | 2.29 | 2.60 |
| Households | 19,895 | 57,153 | 124,010,992 |
| Family Households | 12,942 | 28,129 | 80,755,759 |
| Married couple, w/children | 32.1% | 18.5% | 30.5% |
| Married couple, no children | 40.3% | 30.0% | 42.9% |
| Non Family Households | 6,953 | 29,024 | 43,255,233 |
| Single householder, w/children | 21.7% | 33.7% | 15.8% |
| Single householder, no children | 5.8% | 17.8% | 10.8% |