| | Harrisburg, PA | Hilton Head Island, SC | United States |
| Population | 49,969 | 38,068 | 329,725,481 |
| Female Population | 51.5% | 51.0% | 50.5% |
| Male Population | 48.5% | 49.1% | 49.5% |
| Median Age | 31.6 | 59.1 | 38.4 |
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| Population - 2010 | 49,513 | 37,219 | 309,327,143 |
| Population - 2000 | 48,950 | 33,862 | 285,036,114 |
| Population - 1990 | 52,376 | 23,694 | 251,960,433 |
| Pop. 2000 to Now | 0.8% | 17.0% | 15.6% |
| Pop. 1990 to Now | -5.8% | 67.2% | 30.8% |
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| Population Density | 6,154.6 | 920.3 | 93.4 |
| Land Area | 8.1 | 41.4 | 3,531,905.4 |
| Water Area | 3.7 | 27.8 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Harrisburg, PA | Hilton Head Island, SC | United States |
| Age 0 to 4 | 8.6% | 2.6% | 5.9% |
| Age 5 to 9 | 8.1% | 3.1% | 6.1% |
| Age 10 to 14 | 8.6% | 4.9% | 6.6% |
| Age 15 to 17 | 3.6% | 2.0% | 3.9% |
| Age 18 to 20 | 3.4% | 1.3% | 4.0% |
| Age 21 to 24 | 5.7% | 2.2% | 5.2% |
| Age 25 to 34 | 17.4% | 8.9% | 13.8% |
| Age 35 to 44 | 11.1% | 7.9% | 12.9% |
| Age 45 to 54 | 11.2% | 10.1% | 12.6% |
| Age 55 to 59 | 6.7% | 8.4% | 6.7% |
| Age 60 to 64 | 4.8% | 10.4% | 6.3% |
| Age 65 to 74 | 6.5% | 21.3% | 9.6% |
| Age 75 to 84 | 3.4% | 12.3% | 4.5% |
| Age 85 and over | 0.9% | 4.8% | 1.9% |
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| Race | | | |
| | Harrisburg, PA | Hilton Head Island, SC | United States |
| White | 24.4% | 77.2% | 59.4% |
| Black | 44.0% | 5.7% | 12.2% |
| Asian | 2.6% | 0.8% | 5.6% |
| Native American | 0.2% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.2% | 0.2% |
| Other | 0.4% | 1.1% | 0.4% |
| Two or More Races | 3.3% | 1.0% | 3.2% |
| Hispanic | 25.1% | 14.1% | 18.4% |
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| Marriage & Family | | | |
| | Harrisburg, PA | Hilton Head Island, SC | United States |
| Married Population | 31.4% | 61.0% | 49.8% |
| Currently Married | 27.3% | 59.6% | 48.0% |
| Married but Separated | 4.2% | 1.4% | 1.8% |
| Single Population | 68.6% | 39.0% | 50.2% |
| Never Married | 49.4% | 21.5% | 33.8% |
| Divorced | 13.0% | 9.3% | 10.8% |
| Widowed | 6.1% | 8.2% | 5.6% |
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| Household Size | 2.33 | 2.22 | 2.60 |
| Households | 20,953 | 17,094 | 124,010,992 |
| Family Households | 10,507 | 11,060 | 80,755,759 |
| Married couple, w/children | 15.0% | 13.6% | 30.5% |
| Married couple, no children | 26.1% | 74.2% | 42.9% |
| Non Family Households | 10,446 | 6,034 | 43,255,233 |
| Single householder, w/children | 40.0% | 7.4% | 15.8% |
| Single householder, no children | 18.9% | 4.9% | 10.8% |