| | Lancaster, OH | Topeka, KS | United States |
| Population | 40,360 | 126,802 | 329,725,481 |
| Female Population | 50.4% | 51.8% | 50.5% |
| Male Population | 49.6% | 48.2% | 49.5% |
| Median Age | 39.4 | 38.1 | 38.4 |
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| Population - 2010 | 38,795 | 127,918 | 309,327,143 |
| Population - 2000 | 35,335 | 122,377 | 285,036,114 |
| Population - 1990 | 34,507 | 119,883 | 251,960,433 |
| Pop. 2000 to Now | 15.8% | 1.8% | 15.6% |
| Pop. 1990 to Now | 18.6% | 3.9% | 30.8% |
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| Population Density | 2,140.9 | 2,063.8 | 93.4 |
| Land Area | 18.9 | 61.4 | 3,531,905.4 |
| Water Area | 0.1 | 1.3 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Lancaster, OH | Topeka, KS | United States |
| Age 0 to 4 | 6.6% | 6.1% | 5.9% |
| Age 5 to 9 | 6.5% | 7.1% | 6.1% |
| Age 10 to 14 | 5.5% | 5.9% | 6.6% |
| Age 15 to 17 | 3.8% | 3.7% | 3.9% |
| Age 18 to 20 | 2.9% | 3.7% | 4.0% |
| Age 21 to 24 | 5.8% | 6.0% | 5.2% |
| Age 25 to 34 | 13.8% | 13.2% | 13.8% |
| Age 35 to 44 | 11.5% | 12.3% | 12.9% |
| Age 45 to 54 | 13.2% | 11.1% | 12.6% |
| Age 55 to 59 | 7.0% | 6.3% | 6.7% |
| Age 60 to 64 | 5.5% | 6.5% | 6.3% |
| Age 65 to 74 | 9.6% | 10.0% | 9.6% |
| Age 75 to 84 | 5.5% | 5.3% | 4.5% |
| Age 85 and over | 2.7% | 2.7% | 1.9% |
| space1 | | | |
| Race | | | |
| | Lancaster, OH | Topeka, KS | United States |
| White | 92.1% | 67.0% | 59.4% |
| Black | 1.6% | 10.1% | 12.2% |
| Asian | 0.4% | 1.6% | 5.6% |
| Native American | 0.0% | 0.7% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.1% | 0.4% | 0.4% |
| Two or More Races | 3.6% | 4.4% | 3.2% |
| Hispanic | 2.0% | 15.8% | 18.4% |
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| Marriage & Family | | | |
| | Lancaster, OH | Topeka, KS | United States |
| Married Population | 45.8% | 44.8% | 49.8% |
| Currently Married | 43.4% | 43.3% | 48.0% |
| Married but Separated | 2.4% | 1.5% | 1.8% |
| Single Population | 54.2% | 55.2% | 50.2% |
| Never Married | 30.3% | 32.3% | 33.8% |
| Divorced | 15.5% | 15.4% | 10.8% |
| Widowed | 8.4% | 7.5% | 5.6% |
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| Household Size | 2.38 | 2.26 | 2.60 |
| Households | 16,494 | 54,257 | 124,010,992 |
| Family Households | 9,977 | 29,608 | 80,755,759 |
| Married couple, w/children | 28.8% | 28.6% | 30.5% |
| Married couple, no children | 40.2% | 39.7% | 42.9% |
| Non Family Households | 6,517 | 24,649 | 43,255,233 |
| Single householder, w/children | 19.1% | 20.2% | 15.8% |
| Single householder, no children | 12.0% | 11.5% | 10.8% |