| | Madison, FL | Defiance, OH | United States |
| Population | 2,903 | 17,155 | 329,725,481 |
| Female Population | 48.5% | 51.0% | 50.5% |
| Male Population | 51.5% | 49.0% | 49.5% |
| Median Age | 34.4 | 40.4 | 38.4 |
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| Population - 2010 | 3,030 | 17,165 | 309,327,143 |
| Population - 2000 | 3,061 | 16,465 | 285,036,114 |
| Population - 1990 | 3,345 | 16,768 | 251,960,433 |
| Pop. 2000 to Now | -8.9% | 0.1% | 15.6% |
| Pop. 1990 to Now | -16.6% | -1.7% | 30.8% |
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| Population Density | 1,101.3 | 1,369.6 | 93.4 |
| Land Area | 2.6 | 12.5 | 3,531,905.4 |
| Water Area | 0.1 | 0.5 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Madison, FL | Defiance, OH | United States |
| Age 0 to 4 | 7.8% | 6.3% | 5.9% |
| Age 5 to 9 | 5.3% | 5.9% | 6.1% |
| Age 10 to 14 | 5.4% | 5.1% | 6.6% |
| Age 15 to 17 | 4.1% | 3.4% | 3.9% |
| Age 18 to 20 | 5.0% | 5.8% | 4.0% |
| Age 21 to 24 | 7.5% | 5.6% | 5.2% |
| Age 25 to 34 | 15.8% | 11.9% | 13.8% |
| Age 35 to 44 | 11.4% | 11.9% | 12.9% |
| Age 45 to 54 | 12.9% | 11.2% | 12.6% |
| Age 55 to 59 | 5.2% | 6.4% | 6.7% |
| Age 60 to 64 | 2.4% | 6.9% | 6.3% |
| Age 65 to 74 | 10.5% | 11.8% | 9.6% |
| Age 75 to 84 | 4.6% | 5.9% | 4.5% |
| Age 85 and over | 2.2% | 2.0% | 1.9% |
| space1 | | | |
| Race | | | |
| | Madison, FL | Defiance, OH | United States |
| White | 37.6% | 80.7% | 59.4% |
| Black | 55.8% | 2.8% | 12.2% |
| Asian | 0.0% | 0.1% | 5.6% |
| Native American | 0.0% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.3% | 0.0% | 0.4% |
| Two or More Races | 2.9% | 2.0% | 3.2% |
| Hispanic | 3.3% | 14.1% | 18.4% |
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| Marriage & Family | | | |
| | Madison, FL | Defiance, OH | United States |
| Married Population | 32.9% | 50.4% | 49.8% |
| Currently Married | 31.8% | 47.8% | 48.0% |
| Married but Separated | 1.1% | 2.6% | 1.8% |
| Single Population | 67.1% | 49.6% | 50.2% |
| Never Married | 48.6% | 33.0% | 33.8% |
| Divorced | 10.6% | 11.4% | 10.8% |
| Widowed | 7.9% | 5.2% | 5.6% |
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| Household Size | 2.52 | 2.33 | 2.60 |
| Households | 1,104 | 7,156 | 124,010,992 |
| Family Households | 557 | 4,411 | 80,755,759 |
| Married couple, w/children | 29.1% | 20.9% | 30.5% |
| Married couple, no children | 23.2% | 52.5% | 42.9% |
| Non Family Households | 547 | 2,745 | 43,255,233 |
| Single householder, w/children | 26.9% | 20.7% | 15.8% |
| Single householder, no children | 20.8% | 5.9% | 10.8% |