| | Millsboro, DE | Frederick, MD | United States |
| Population | 6,542 | 76,376 | 329,725,481 |
| Female Population | 58.9% | 51.0% | 50.5% |
| Male Population | 41.1% | 49.0% | 49.5% |
| Median Age | 43.3 | 36.9 | 38.4 |
| space3 | | | |
| Population - 2010 | 3,871 | 65,508 | 309,327,143 |
| Population - 2000 | 2,360 | 52,767 | 285,036,114 |
| Population - 1990 | 1,643 | 40,148 | 251,960,433 |
| Pop. 2000 to Now | 97.7% | 38.9% | 15.6% |
| Pop. 1990 to Now | 183.9% | 82.6% | 30.8% |
| space4 | | | |
| Population Density | 1,761.0 | 3,297.3 | 93.4 |
| Land Area | 3.7 | 23.2 | 3,531,905.4 |
| Water Area | 0.2 | 0.2 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Millsboro, DE | Frederick, MD | United States |
| Age 0 to 4 | 5.8% | 5.9% | 5.9% |
| Age 5 to 9 | 5.6% | 5.8% | 6.1% |
| Age 10 to 14 | 7.6% | 6.7% | 6.6% |
| Age 15 to 17 | 4.4% | 3.7% | 3.9% |
| Age 18 to 20 | 2.6% | 3.6% | 4.0% |
| Age 21 to 24 | 4.5% | 5.5% | 5.2% |
| Age 25 to 34 | 7.6% | 15.7% | 13.8% |
| Age 35 to 44 | 16.2% | 14.3% | 12.9% |
| Age 45 to 54 | 7.7% | 13.1% | 12.6% |
| Age 55 to 59 | 5.9% | 6.9% | 6.7% |
| Age 60 to 64 | 4.9% | 5.0% | 6.3% |
| Age 65 to 74 | 17.1% | 8.0% | 9.6% |
| Age 75 to 84 | 9.0% | 3.9% | 4.5% |
| Age 85 and over | 1.1% | 1.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Millsboro, DE | Frederick, MD | United States |
| White | 76.0% | 54.9% | 59.4% |
| Black | 17.9% | 17.1% | 12.2% |
| Asian | 0.9% | 5.1% | 5.6% |
| Native American | 0.5% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.2% | 0.4% |
| Two or More Races | 4.1% | 4.9% | 3.2% |
| Hispanic | 0.7% | 17.5% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Millsboro, DE | Frederick, MD | United States |
| Married Population | 55.4% | 47.9% | 49.8% |
| Currently Married | 52.9% | 45.7% | 48.0% |
| Married but Separated | 2.5% | 2.2% | 1.8% |
| Single Population | 44.6% | 52.1% | 50.2% |
| Never Married | 21.9% | 35.0% | 33.8% |
| Divorced | 10.5% | 11.7% | 10.8% |
| Widowed | 12.2% | 5.4% | 5.6% |
| space5 | | | |
| Household Size | 2.31 | 2.43 | 2.60 |
| Households | 2,758 | 30,644 | 124,010,992 |
| Family Households | 1,798 | 18,686 | 80,755,759 |
| Married couple, w/children | 28.1% | 34.7% | 30.5% |
| Married couple, no children | 42.2% | 35.7% | 42.9% |
| Non Family Households | 960 | 11,958 | 43,255,233 |
| Single householder, w/children | 21.6% | 18.2% | 15.8% |
| Single householder, no children | 8.1% | 11.4% | 10.8% |