| | Millsboro, PA | Wellsboro, PA | United States |
| Population | 374 | 3,440 | 329,725,481 |
| Female Population | 54.8% | 51.2% | 50.5% |
| Male Population | 45.2% | 48.8% | 49.5% |
| Median Age | 34.9 | 42.7 | 38.4 |
| space3 | | | |
| Population - 2010 | 465 | 3,265 | 309,327,143 |
| Population - 2000 | 717 | 3,328 | 285,036,114 |
| Population - 1990 | 748 | 3,430 | 251,960,433 |
| Pop. 2000 to Now | -18.4% | -3.7% | 15.6% |
| Pop. 1990 to Now | -21.8% | -6.6% | 30.8% |
| space4 | | | |
| Population Density | 474.6 | 701.8 | 93.4 |
| Land Area | 0.8 | 4.9 | 3,531,905.4 |
| Water Area | 0.0 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Millsboro, PA | Wellsboro, PA | United States |
| Age 0 to 4 | 5.1% | 3.9% | 5.9% |
| Age 5 to 9 | 4.5% | 8.9% | 6.1% |
| Age 10 to 14 | 1.6% | 5.8% | 6.6% |
| Age 15 to 17 | 7.8% | 3.2% | 3.9% |
| Age 18 to 20 | 23.3% | 2.8% | 4.0% |
| Age 21 to 24 | 1.1% | 4.3% | 5.2% |
| Age 25 to 34 | 7.2% | 10.8% | 13.8% |
| Age 35 to 44 | 21.4% | 14.9% | 12.9% |
| Age 45 to 54 | 21.1% | 11.4% | 12.6% |
| Age 55 to 59 | 6.2% | 5.8% | 6.7% |
| Age 60 to 64 | 0.0% | 3.4% | 6.3% |
| Age 65 to 74 | 0.8% | 14.6% | 9.6% |
| Age 75 to 84 | 0.0% | 5.6% | 4.5% |
| Age 85 and over | 0.0% | 4.7% | 1.9% |
| space1 | | | |
| Race | | | |
| | Millsboro, PA | Wellsboro, PA | United States |
| White | 100.0% | 96.1% | 59.4% |
| Black | 0.0% | 1.5% | 12.2% |
| Asian | 0.0% | 0.7% | 5.6% |
| Native American | 0.0% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 0.0% | 1.3% | 3.2% |
| Hispanic | 0.0% | 0.4% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Millsboro, PA | Wellsboro, PA | United States |
| Married Population | 57.8% | 49.0% | 49.8% |
| Currently Married | 53.3% | 48.1% | 48.0% |
| Married but Separated | 4.5% | 0.9% | 1.8% |
| Single Population | 42.2% | 51.0% | 50.2% |
| Never Married | 42.2% | 28.4% | 33.8% |
| Divorced | 0.0% | 13.4% | 10.8% |
| Widowed | 0.0% | 9.2% | 5.6% |
| space5 | | | |
| Household Size | 3.04 | 2.23 | 2.60 |
| Households | 123 | 1,477 | 124,010,992 |
| Family Households | 100 | 800 | 80,755,759 |
| Married couple, w/children | 40.0% | 28.8% | 30.5% |
| Married couple, no children | 48.0% | 47.3% | 42.9% |
| Non Family Households | 23 | 677 | 43,255,233 |
| Single householder, w/children | 12.0% | 19.5% | 15.8% |
| Single householder, no children | 0.0% | 4.5% | 10.8% |