| | Muleshoe, TX | Tampa, FL | United States |
| Population | 5,781 | 380,476 | 329,725,481 |
| Female Population | 53.4% | 50.4% | 50.5% |
| Male Population | 46.7% | 49.6% | 49.5% |
| Median Age | 32.9 | 35.9 | 38.4 |
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| Population - 2010 | 5,182 | 337,156 | 309,327,143 |
| Population - 2000 | 4,530 | 303,447 | 285,036,114 |
| Population - 1990 | 4,571 | 280,015 | 251,960,433 |
| Pop. 2000 to Now | 6.5% | 34.3% | 15.6% |
| Pop. 1990 to Now | 5.5% | 45.6% | 30.8% |
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| Population Density | 1,684.9 | 3,337.4 | 93.4 |
| Land Area | 3.4 | 114.0 | 3,531,905.4 |
| Water Area | 0.0 | 61.8 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Muleshoe, TX | Tampa, FL | United States |
| Age 0 to 4 | 6.7% | 6.2% | 5.9% |
| Age 5 to 9 | 5.9% | 5.9% | 6.1% |
| Age 10 to 14 | 9.9% | 5.9% | 6.6% |
| Age 15 to 17 | 6.7% | 3.5% | 3.9% |
| Age 18 to 20 | 3.9% | 4.6% | 4.0% |
| Age 21 to 24 | 5.6% | 5.4% | 5.2% |
| Age 25 to 34 | 13.7% | 17.2% | 13.8% |
| Age 35 to 44 | 16.5% | 13.9% | 12.9% |
| Age 45 to 54 | 7.2% | 13.0% | 12.6% |
| Age 55 to 59 | 4.8% | 5.9% | 6.7% |
| Age 60 to 64 | 6.3% | 5.7% | 6.3% |
| Age 65 to 74 | 7.6% | 7.6% | 9.6% |
| Age 75 to 84 | 2.8% | 3.8% | 4.5% |
| Age 85 and over | 2.5% | 1.4% | 1.9% |
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| Race | | | |
| | Muleshoe, TX | Tampa, FL | United States |
| White | 25.6% | 44.4% | 59.4% |
| Black | 0.2% | 21.1% | 12.2% |
| Asian | 0.6% | 4.5% | 5.6% |
| Native American | 1.1% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.1% | 0.2% |
| Other | 0.0% | 0.3% | 0.4% |
| Two or More Races | 0.0% | 3.3% | 3.2% |
| Hispanic | 72.5% | 26.2% | 18.4% |
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| Marriage & Family | | | |
| | Muleshoe, TX | Tampa, FL | United States |
| Married Population | 50.6% | 41.6% | 49.8% |
| Currently Married | 46.8% | 39.1% | 48.0% |
| Married but Separated | 3.7% | 2.5% | 1.8% |
| Single Population | 49.4% | 58.4% | 50.2% |
| Never Married | 35.3% | 40.3% | 33.8% |
| Divorced | 5.6% | 13.1% | 10.8% |
| Widowed | 8.5% | 5.0% | 5.6% |
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| Household Size | 3.66 | 2.41 | 2.60 |
| Households | 1,526 | 153,163 | 124,010,992 |
| Family Households | 1,109 | 82,968 | 80,755,759 |
| Married couple, w/children | 37.2% | 28.0% | 30.5% |
| Married couple, no children | 33.4% | 37.3% | 42.9% |
| Non Family Households | 417 | 70,195 | 43,255,233 |
| Single householder, w/children | 26.8% | 21.0% | 15.8% |
| Single householder, no children | 2.7% | 13.7% | 10.8% |