| | Neosho, MO | Yankton, SD | United States |
| Population | 12,439 | 15,332 | 329,725,481 |
| Female Population | 50.1% | 48.7% | 50.5% |
| Male Population | 49.9% | 51.3% | 49.5% |
| Median Age | 34.5 | 40.4 | 38.4 |
| space3 | | | |
| Population - 2010 | 11,850 | 14,470 | 309,327,143 |
| Population - 2000 | 10,505 | 13,528 | 285,036,114 |
| Population - 1990 | 9,254 | 12,703 | 251,960,433 |
| Pop. 2000 to Now | 15.3% | 8.3% | 15.6% |
| Pop. 1990 to Now | 30.9% | 15.3% | 30.8% |
| space4 | | | |
| Population Density | 790.8 | 1,789.5 | 93.4 |
| Land Area | 15.7 | 8.6 | 3,531,905.4 |
| Water Area | 0.0 | 0.2 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | Neosho, MO | Yankton, SD | United States |
| Age 0 to 4 | 7.4% | 5.9% | 5.9% |
| Age 5 to 9 | 7.5% | 5.2% | 6.1% |
| Age 10 to 14 | 7.8% | 6.5% | 6.6% |
| Age 15 to 17 | 4.8% | 3.7% | 3.9% |
| Age 18 to 20 | 4.7% | 3.5% | 4.0% |
| Age 21 to 24 | 5.4% | 6.5% | 5.2% |
| Age 25 to 34 | 13.4% | 11.0% | 13.8% |
| Age 35 to 44 | 13.2% | 12.9% | 12.9% |
| Age 45 to 54 | 10.5% | 11.3% | 12.6% |
| Age 55 to 59 | 6.8% | 5.7% | 6.7% |
| Age 60 to 64 | 3.9% | 7.4% | 6.3% |
| Age 65 to 74 | 9.7% | 10.4% | 9.6% |
| Age 75 to 84 | 3.2% | 7.0% | 4.5% |
| Age 85 and over | 1.9% | 3.1% | 1.9% |
| space1 | | | |
| Race | | | |
| | Neosho, MO | Yankton, SD | United States |
| White | 74.2% | 85.2% | 59.4% |
| Black | 1.8% | 1.8% | 12.2% |
| Asian | 0.4% | 0.2% | 5.6% |
| Native American | 1.2% | 3.9% | 0.6% |
| Hawaiian, Pacific Islander | 2.7% | 0.0% | 0.2% |
| Other | 0.0% | 0.0% | 0.4% |
| Two or More Races | 7.8% | 2.8% | 3.2% |
| Hispanic | 11.8% | 6.0% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | Neosho, MO | Yankton, SD | United States |
| Married Population | 52.5% | 47.8% | 49.8% |
| Currently Married | 49.8% | 46.7% | 48.0% |
| Married but Separated | 2.6% | 1.1% | 1.8% |
| Single Population | 47.5% | 52.2% | 50.2% |
| Never Married | 27.2% | 35.2% | 33.8% |
| Divorced | 13.6% | 10.6% | 10.8% |
| Widowed | 6.7% | 6.5% | 5.6% |
| space5 | | | |
| Household Size | 2.69 | 2.15 | 2.60 |
| Households | 4,449 | 6,577 | 124,010,992 |
| Family Households | 2,860 | 3,618 | 80,755,759 |
| Married couple, w/children | 37.7% | 29.7% | 30.5% |
| Married couple, no children | 39.6% | 47.9% | 42.9% |
| Non Family Households | 1,589 | 2,959 | 43,255,233 |
| Single householder, w/children | 17.9% | 16.9% | 15.8% |
| Single householder, no children | 4.8% | 5.6% | 10.8% |