| | Potomac, MD | Frederick, MD | United States |
| Population | 46,891 | 76,376 | 329,725,481 |
| Female Population | 51.7% | 51.0% | 50.5% |
| Male Population | 48.3% | 49.0% | 49.5% |
| Median Age | 46.6 | 36.9 | 38.4 |
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| Population - 2010 | 44,785 | 65,508 | 309,327,143 |
| Population - 2000 | 44,822 | 52,767 | 285,036,114 |
| Population - 1990 | 45,634 | 40,148 | 251,960,433 |
| Pop. 2000 to Now | 4.0% | 38.9% | 15.6% |
| Pop. 1990 to Now | 2.1% | 82.6% | 30.8% |
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| Population Density | 1,865.7 | 3,297.3 | 93.4 |
| Land Area | 25.1 | 23.2 | 3,531,905.4 |
| Water Area | 1.5 | 0.2 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | Potomac, MD | Frederick, MD | United States |
| Age 0 to 4 | 4.5% | 5.9% | 5.9% |
| Age 5 to 9 | 5.9% | 5.8% | 6.1% |
| Age 10 to 14 | 8.1% | 6.7% | 6.6% |
| Age 15 to 17 | 6.2% | 3.7% | 3.9% |
| Age 18 to 20 | 3.3% | 3.6% | 4.0% |
| Age 21 to 24 | 3.1% | 5.5% | 5.2% |
| Age 25 to 34 | 5.6% | 15.7% | 13.8% |
| Age 35 to 44 | 10.9% | 14.3% | 12.9% |
| Age 45 to 54 | 15.7% | 13.1% | 12.6% |
| Age 55 to 59 | 7.8% | 6.9% | 6.7% |
| Age 60 to 64 | 7.1% | 5.0% | 6.3% |
| Age 65 to 74 | 11.8% | 8.0% | 9.6% |
| Age 75 to 84 | 7.3% | 3.9% | 4.5% |
| Age 85 and over | 2.7% | 1.8% | 1.9% |
| space1 | | | |
| Race | | | |
| | Potomac, MD | Frederick, MD | United States |
| White | 59.8% | 54.9% | 59.4% |
| Black | 5.8% | 17.1% | 12.2% |
| Asian | 20.0% | 5.1% | 5.6% |
| Native American | 0.0% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.6% | 0.2% | 0.4% |
| Two or More Races | 2.9% | 4.9% | 3.2% |
| Hispanic | 10.7% | 17.5% | 18.4% |
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| Marriage & Family | | | |
| | Potomac, MD | Frederick, MD | United States |
| Married Population | 66.1% | 47.9% | 49.8% |
| Currently Married | 65.2% | 45.7% | 48.0% |
| Married but Separated | 0.8% | 2.2% | 1.8% |
| Single Population | 34.0% | 52.1% | 50.2% |
| Never Married | 23.2% | 35.0% | 33.8% |
| Divorced | 5.5% | 11.7% | 10.8% |
| Widowed | 5.3% | 5.4% | 5.6% |
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| Household Size | 2.82 | 2.43 | 2.60 |
| Households | 16,514 | 30,644 | 124,010,992 |
| Family Households | 13,115 | 18,686 | 80,755,759 |
| Married couple, w/children | 41.0% | 34.7% | 30.5% |
| Married couple, no children | 46.5% | 35.7% | 42.9% |
| Non Family Households | 3,399 | 11,958 | 43,255,233 |
| Single householder, w/children | 6.1% | 18.2% | 15.8% |
| Single householder, no children | 6.4% | 11.4% | 10.8% |