| | San Francisco, CA | Bethesda, MD | United States |
| Population | 865,933 | 66,294 | 329,725,481 |
| Female Population | 48.8% | 51.9% | 50.5% |
| Male Population | 51.2% | 48.1% | 49.5% |
| Median Age | 38.7 | 43 | 38.4 |
| space3 | | | |
| Population - 2010 | 805,519 | 58,537 | 309,327,143 |
| Population - 2000 | 776,733 | 55,277 | 285,036,114 |
| Population - 1990 | 723,959 | 62,936 | 251,960,433 |
| Pop. 2000 to Now | 11.6% | 16.3% | 15.6% |
| Pop. 1990 to Now | 19.7% | 2.2% | 30.8% |
| space4 | | | |
| Population Density | 18,478.0 | 4,998.8 | 93.4 |
| Land Area | 46.9 | 13.3 | 3,531,905.4 |
| Water Area | 185.0 | 0.1 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | San Francisco, CA | Bethesda, MD | United States |
| Age 0 to 4 | 4.4% | 5.3% | 5.9% |
| Age 5 to 9 | 3.5% | 6.9% | 6.1% |
| Age 10 to 14 | 3.7% | 7.0% | 6.6% |
| Age 15 to 17 | 2.0% | 4.1% | 3.9% |
| Age 18 to 20 | 2.3% | 2.3% | 4.0% |
| Age 21 to 24 | 4.5% | 4.1% | 5.2% |
| Age 25 to 34 | 22.6% | 10.4% | 13.8% |
| Age 35 to 44 | 16.1% | 12.3% | 12.9% |
| Age 45 to 54 | 13.2% | 15.5% | 12.6% |
| Age 55 to 59 | 6.0% | 7.2% | 6.7% |
| Age 60 to 64 | 5.7% | 6.2% | 6.3% |
| Age 65 to 74 | 9.1% | 10.9% | 9.6% |
| Age 75 to 84 | 4.3% | 4.9% | 4.5% |
| Age 85 and over | 2.5% | 2.9% | 1.9% |
| space1 | | | |
| Race | | | |
| | San Francisco, CA | Bethesda, MD | United States |
| White | 39.2% | 70.1% | 59.4% |
| Black | 4.9% | 4.7% | 12.2% |
| Asian | 34.1% | 11.3% | 5.6% |
| Native American | 0.2% | 0.0% | 0.6% |
| Hawaiian, Pacific Islander | 0.3% | 0.0% | 0.2% |
| Other | 0.6% | 0.7% | 0.4% |
| Two or More Races | 5.3% | 4.2% | 3.2% |
| Hispanic | 15.4% | 9.0% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | San Francisco, CA | Bethesda, MD | United States |
| Married Population | 41.5% | 60.9% | 49.8% |
| Currently Married | 40.1% | 60.2% | 48.0% |
| Married but Separated | 1.4% | 0.7% | 1.8% |
| Single Population | 58.5% | 39.1% | 50.2% |
| Never Married | 46.0% | 26.6% | 33.8% |
| Divorced | 8.0% | 8.0% | 10.8% |
| Widowed | 4.5% | 4.4% | 5.6% |
| space5 | | | |
| Household Size | 2.34 | 2.44 | 2.60 |
| Households | 361,222 | 26,930 | 124,010,992 |
| Family Households | 170,465 | 17,529 | 80,755,759 |
| Married couple, w/children | 28.8% | 42.0% | 30.5% |
| Married couple, no children | 47.0% | 45.9% | 42.9% |
| Non Family Households | 190,757 | 9,401 | 43,255,233 |
| Single householder, w/children | 10.0% | 6.5% | 15.8% |
| Single householder, no children | 14.2% | 5.6% | 10.8% |