| | San Luis, AZ | Nogales, AZ | United States |
| Population | 35,289 | 19,829 | 329,725,481 |
| Female Population | 45.4% | 52.4% | 50.5% |
| Male Population | 54.6% | 47.6% | 49.5% |
| Median Age | 30.8 | 36.9 | 38.4 |
| space3 | | | |
| Population - 2010 | 28,428 | 20,805 | 309,327,143 |
| Population - 2000 | 15,322 | 20,878 | 285,036,114 |
| Population - 1990 | 4,212 | 19,489 | 251,960,433 |
| Pop. 2000 to Now | 136.5% | -3.7% | 15.6% |
| Pop. 1990 to Now | 760.5% | 3.2% | 30.8% |
| space4 | | | |
| Population Density | 1,034.2 | 952.5 | 93.4 |
| Land Area | 34.1 | 20.8 | 3,531,905.4 |
| Water Area | 0.1 | 0.0 | 264,836.8 |
| space | | | |
| Est. Total Population By Age | | | |
| | San Luis, AZ | Nogales, AZ | United States |
| Age 0 to 4 | 7.7% | 5.8% | 5.9% |
| Age 5 to 9 | 6.4% | 7.3% | 6.1% |
| Age 10 to 14 | 10.2% | 7.6% | 6.6% |
| Age 15 to 17 | 5.6% | 5.8% | 3.9% |
| Age 18 to 20 | 5.4% | 5.0% | 4.0% |
| Age 21 to 24 | 6.3% | 4.2% | 5.2% |
| Age 25 to 34 | 15.5% | 12.3% | 13.8% |
| Age 35 to 44 | 12.6% | 11.6% | 12.9% |
| Age 45 to 54 | 12.4% | 11.6% | 12.6% |
| Age 55 to 59 | 4.9% | 5.7% | 6.7% |
| Age 60 to 64 | 4.1% | 4.5% | 6.3% |
| Age 65 to 74 | 6.4% | 9.9% | 9.6% |
| Age 75 to 84 | 2.0% | 5.8% | 4.5% |
| Age 85 and over | 0.6% | 2.9% | 1.9% |
| space1 | | | |
| Race | | | |
| | San Luis, AZ | Nogales, AZ | United States |
| White | 3.3% | 2.6% | 59.4% |
| Black | 1.2% | 0.6% | 12.2% |
| Asian | 0.1% | 0.5% | 5.6% |
| Native American | 0.6% | 0.2% | 0.6% |
| Hawaiian, Pacific Islander | 0.0% | 0.0% | 0.2% |
| Other | 0.0% | 0.2% | 0.4% |
| Two or More Races | 0.0% | 2.0% | 3.2% |
| Hispanic | 94.8% | 93.9% | 18.4% |
| space2 | | | |
| Marriage & Family | | | |
| | San Luis, AZ | Nogales, AZ | United States |
| Married Population | 52.6% | 48.0% | 49.8% |
| Currently Married | 48.9% | 44.1% | 48.0% |
| Married but Separated | 3.7% | 3.9% | 1.8% |
| Single Population | 47.4% | 52.0% | 50.2% |
| Never Married | 37.3% | 33.0% | 33.8% |
| Divorced | 7.2% | 11.6% | 10.8% |
| Widowed | 2.9% | 7.4% | 5.6% |
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| Household Size | 3.67 | 2.86 | 2.60 |
| Households | 8,812 | 6,839 | 124,010,992 |
| Family Households | 7,771 | 4,829 | 80,755,759 |
| Married couple, w/children | 40.1% | 30.6% | 30.5% |
| Married couple, no children | 27.2% | 32.0% | 42.9% |
| Non Family Households | 1,041 | 2,010 | 43,255,233 |
| Single householder, w/children | 24.7% | 20.9% | 15.8% |
| Single householder, no children | 8.0% | 16.5% | 10.8% |