| | St. Matthews, SC | DeLand, FL | United States |
| Population | 2,038 | 36,528 | 329,725,481 |
| Female Population | 52.9% | 55.7% | 50.5% |
| Male Population | 47.2% | 44.3% | 49.5% |
| Median Age | 41.8 | 40.2 | 38.4 |
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| Population - 2010 | 2,014 | 26,895 | 309,327,143 |
| Population - 2000 | 2,107 | 20,904 | 285,036,114 |
| Population - 1990 | 2,345 | 16,491 | 251,960,433 |
| Pop. 2000 to Now | -9.7% | 72.3% | 15.6% |
| Pop. 1990 to Now | -18.9% | 118.4% | 30.8% |
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| Population Density | 1,060.4 | 1,940.7 | 93.4 |
| Land Area | 1.9 | 18.8 | 3,531,905.4 |
| Water Area | 0.0 | 0.2 | 264,836.8 |
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| Est. Total Population By Age | | | |
| | St. Matthews, SC | DeLand, FL | United States |
| Age 0 to 4 | 7.4% | 6.3% | 5.9% |
| Age 5 to 9 | 3.8% | 5.8% | 6.1% |
| Age 10 to 14 | 5.9% | 5.1% | 6.6% |
| Age 15 to 17 | 2.3% | 3.9% | 3.9% |
| Age 18 to 20 | 2.0% | 6.9% | 4.0% |
| Age 21 to 24 | 5.4% | 5.4% | 5.2% |
| Age 25 to 34 | 15.1% | 10.8% | 13.8% |
| Age 35 to 44 | 12.4% | 11.6% | 12.9% |
| Age 45 to 54 | 5.3% | 11.0% | 12.6% |
| Age 55 to 59 | 6.1% | 6.7% | 6.7% |
| Age 60 to 64 | 7.2% | 5.7% | 6.3% |
| Age 65 to 74 | 15.8% | 11.7% | 9.6% |
| Age 75 to 84 | 9.1% | 5.6% | 4.5% |
| Age 85 and over | 2.3% | 3.3% | 1.9% |
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| Race | | | |
| | St. Matthews, SC | DeLand, FL | United States |
| White | 38.5% | 62.7% | 59.4% |
| Black | 60.0% | 14.9% | 12.2% |
| Asian | 0.3% | 1.8% | 5.6% |
| Native American | 0.2% | 0.1% | 0.6% |
| Hawaiian, Pacific Islander | 0.1% | 0.0% | 0.2% |
| Other | 0.0% | 0.2% | 0.4% |
| Two or More Races | 0.0% | 1.4% | 3.2% |
| Hispanic | 0.8% | 18.9% | 18.4% |
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| Marriage & Family | | | |
| | St. Matthews, SC | DeLand, FL | United States |
| Married Population | 34.0% | 46.3% | 49.8% |
| Currently Married | 30.4% | 44.6% | 48.0% |
| Married but Separated | 3.6% | 1.7% | 1.8% |
| Single Population | 66.0% | 53.7% | 50.2% |
| Never Married | 42.9% | 32.7% | 33.8% |
| Divorced | 8.1% | 12.3% | 10.8% |
| Widowed | 15.0% | 8.8% | 5.6% |
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| Household Size | 2.42 | 2.42 | 2.60 |
| Households | 792 | 14,006 | 124,010,992 |
| Family Households | 477 | 8,669 | 80,755,759 |
| Married couple, w/children | 17.2% | 27.2% | 30.5% |
| Married couple, no children | 31.7% | 46.2% | 42.9% |
| Non Family Households | 315 | 5,337 | 43,255,233 |
| Single householder, w/children | 23.1% | 15.0% | 15.8% |
| Single householder, no children | 28.1% | 11.6% | 10.8% |